Antibiotic resistance represents an increasingly urgent problem in the modern world, which we try to solve with several different measures. One of which is the search for new molecules with potential antibacterial properties. In our research work, we first focused on the search for substances with potential antibacterial properties, which we observed among compounds with a phenidone base. After analyzing these compounds on diffusion antibiograms, we further defined them on microtiter plates, where we were interested in the dependence of the growth of bacterial strains on the concentration of the added compound, as well as the degree of inhibition. In our work we used four bacterial strains: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus thuringiensis. Three of these strains, E. coli, P. aeruginosa and S. aureus, are common causes of community-acquired and nosocomial infections in humans. We found that the inhibition of bacterial growth in the presence of compounds with a phenidone base increased with the concentration of the added compound in as many as 8 out of 12 cases, and in 6 out of 12 cases the degree of inhibition was more than 50 %. Our and similar research works represent only a small beginning in the high potential use of various compounds in the treatment of infections by the mentioned bacterial strains.
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