Unique relationships between phages and endospore-forming hosts

Butala, Matej (author), Dragoš, Anna (author)

As part of their survival strategy under harsh environmental conditions, endospore-forming bacteria can trigger a sporulation developmental program. Although the regulatory cascades that precisely control the transformation of vegetative bacteria into mother cells and resilient spores have been described in detail, less is known about how bacteriophages that prey on endospore-formers exploit sporulation. Herein, we argue that phages infecting these bacteria have evolved several specific molecular mechanisms, not yet known in other bacteria, that manifest from the phage-driven alliance to negative effects on the host. We anticipate that the relationships between phages and endospore-formers outlined here will inspire studies on phage ecology and evolution, and could facilitate important advances in the development of phage therapies against pathogenic spore-formers.

• Language: English
• Keywords: lysogeny, sporulation, Bacillus, phage–host interaction
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: BF - Biotechnical Faculty
• Publication status: Published
• Publication version: Version of Record
• Year: 2023
• Number of pages: Str. 498-510
• Numbering: Vol. 31, no. 5
• PID: 20.500.12556/RUL-145734
• UDC: 579.25/.26:578.347
• ISSN on article: 0966-842X
• DOI: 10.1016/j.tim.2022.11.009
• COBISS.SI-ID: 135140099
• Publication date in RUL: 11.05.2023

Record is a part of a journal

• Title: Trends in microbiology
• Shortened title: Trends microbiol.
• Publisher: Elsevier
• ISSN: 0966-842X
• COBISS.SI-ID: 15452677

Licences

• License: CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
• Link: http://creativecommons.org/licenses/by-nc-nd/4.0/
• Description: The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

Secondary language

• Language: Slovenian
• Keywords: ekologija mikroorganizmov, bakteriofagi, sporogene bakterije