Molecular mechanisms related to responses to oxidative stress and antioxidative therapies in COVID-19 : a systematic review

Tsermpini, Evangelia Eirini (author), Glamočlija, Una (author), Ulucan-Karnak, Fulden (author), Redenšek Trampuž, Sara (author), Dolžan, Vita (author)

The coronavirus disease (COVID-19) pandemic is a leading global health and economic challenge. What defines the disease’s progression is not entirely understood, but there are strong indications that oxidative stress and the defense against reactive oxygen species are crucial players. A big influx of immune cells to the site of infection is marked by the increase in reactive oxygen and nitrogen species. Our article aims to highlight the critical role of oxidative stress in the emergence and severity of COVID-19 and, more importantly, to shed light on the underlying molecular and genetic mechanisms. We have reviewed the available literature and clinical trials to extract the relevant genetic variants within the oxidative stress pathway associated with COVID-19 and the anti-oxidative therapies currently evaluated in the clinical trials for COVID-19 treatment, in particular clinical trials on glutathione and N-acetylcysteine.

• Language: English
• Keywords: COVID-19, oxidative stress, genetics, antioxidant enzymes, anti-oxidative therapies, glutathione, N-acetylcysteine
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2022
• Number of pages: 37 str.
• Numbering: Vol. 11, iss. 8, art. 1609
• PID: 20.500.12556/RUL-145247
• UDC: 616.9
• ISSN on article: 2076-3921
• DOI: 10.3390/antiox11081609
• COBISS.SI-ID: 118709507
• Publication date in RUL: 13.04.2023

Record is a part of a journal

• Title: Antioxidants
• Shortened title: Antioxidants
• Publisher: MDPI
• ISSN: 2076-3921
• COBISS.SI-ID: 522976025

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: COVID-19, oksidativni stres, genetika

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P1-0170
• Name: Molekulski mehanizmi uravnavanja celičnih procesov v povezavi z nekaterimi boleznimi pri človeku