An analysis of electrophilic aromatic substitution : a "complex approach"

Stamenković, Nikola (author), Poklar Ulrih, Nataša (author), Cerkovnik, Janez (author)

Electrophilic aromatic substitution (EAS) is one of the most widely researched transforms in synthetic organic chemistry. Numerous studies have been carried out to provide an understanding of the nature of its reactivity pattern. There is now a need for a concise and general, but detailed and up-to-date, overview. The basic principles behind EAS are essential to our understanding of what the mechanisms underlying EAS are. To date, textbook overviews of EAS have provided little information about the mechanistic pathways and chemical species involved. In this review, the aim is to gather and present the up-to-date information relating to reactivity in EAS, with the implication that some of the key concepts will be discussed in a scientifically concise manner. In addition, the information presented herein suggests certain new possibilities to advance EAS theory, with particular emphasis on the role of modern instrumental and theoretical techniques in EAS reactivity monitoring.

• Language: English
• Keywords: physical chemistry, chemical reactions, elecrophilic aromatic substitution, synthesis of aromatic compounds
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: BF - Biotechnical Faculty; FKKT - Faculty of Chemistry and Chemical Technology
• Publication status: Published
• Publication version: Version of Record
• Year: 2021
• Number of pages: Str. 5051-5068
• Numbering: Vol. 23, iss. 9
• PID: 20.500.12556/RUL-144751
• UDC: 544.433.22
• ISSN on article: 1463-9076
• DOI: 10.1039/d0cp05245k
• COBISS.SI-ID: 49484035
• Publication date in RUL: 10.03.2023

Record is a part of a journal

• Title: PCCP. Physical chemistry chemical physics
• Shortened title: PCCP. Phys. chem. chem. phys.
• Publisher: Royal Society of Chemistry
• ISSN: 1463-9076
• COBISS.SI-ID: 20139269

Licences

• License: CC BY-NC 3.0, Creative Commons Attribution-NonCommercial 3.0 Unported
• Link: http://creativecommons.org/licenses/by-nc/3.0/
• Description: You are free to reproduce and redistribute the material in any medium or format. You are free to remix, transform, and build upon the material. You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Secondary language

• Language: Slovenian
• Keywords: fizikalna kemija, kemijske reakcije, elektrofilna aromatska substitucija, sinteza aromatskih spojin

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P1-0230
• Name: Organska kemija: sinteza, struktura in aplikacija

• Funder: ARRS - Slovenian Research Agency
• Project number: P4-0121
• Name: Biokemijska in biofizikalno-kemijska karakterizacija naravnih snovi