Reparative perineural hyperplasia in the gastric wall : a histologic mimic of perineural invasion

Bošnjak, Matic (author), Kojc, Nika (author)

Reparative perineural hyperplasia is an incidental and probably underreported reactive histologic finding thus far only reported in the setting of healing wounds or adjacent to a dermatofibroma in cutaneous specimens. It is characterized by a focal concentric proliferation of cytologically bland spindled perineurial cells and is hence considered a benign histologic mimic of neoplastic perineural invasion. Thus, it may present a diagnostic pitfall and we therefore consider it as a valuable entity to be aware of. To the best of our knowledge, this brief case report is the first to convey that reparative perineural hyperplasia may also occur in the gastrointestinal tract. It may therefore be a ubiquitous reactive histological phenomenon relating to previous surgical or traumatic wounds in various sites, that is, outside the thus far established setting of skin reexcision specimens.

• Language: English
• Keywords: perineural invasion, reparative perineural hyperplasia, immunohistochemistry, histologic mimic, gastrointestinal tract
• Work type: Article
• Typology: 1.03 - Short Scientific Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2021
• Number of pages: Str. 903-905
• Numbering: Vol. 29, iss. 8
• PID: 20.500.12556/RUL-144111
• UDC: 616.3
• ISSN on article: 1066-8969
• DOI: 10.1177/10668969211013469
• COBISS.SI-ID: 70124803
• Publication date in RUL: 01.02.2023

Record is a part of a journal

• Title: International journal of surgical pathology
• Shortened title: Int. j. surg. pathol.
• Publisher: SAGE
• ISSN: 1066-8969
• COBISS.SI-ID: 75899

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: perinevralna invazija, reparativna perinevralna hiperplazija, imunohistokemija