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Circulating estradiol and its biologically active metabolites in endometriosis and in relation to pain symptoms
ID
Emond, Jean-Philippe
(
Author
),
ID
Caron, Patrick
(
Author
),
ID
Pušić Novak, Maja
(
Author
),
ID
Turcotte, Véronique
(
Author
),
ID
Simonyan, David
(
Author
),
ID
Vogler, Andrej
(
Author
),
ID
Osredkar, Joško
(
Author
),
ID
Lanišnik-Rižner, Tea
(
Author
),
ID
Guillemette, Chantal
(
Author
)
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MD5: 09B973BC0A2F92605E890BDC91A47141
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https://www.frontiersin.org/articles/10.3389/fendo.2022.1034614/full
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Abstract
Objectives: Endometriosis (EM) is an estrogen-dominant inflammatory disease linked to infertility that affects women of reproductive age. EM lesions respond to hormonal signals that regulate uterine tissue growth and trigger inflammation and pain. The objective of this study was to evaluate whether estradiol (E2) and its biologically active metabolites are differentially associated with EM given their estrogenic and non-estrogenic actions including proliferative and inflammatory properties. Design: We performed a retrospective study of 209 EM cases and 115 women without EM. Methods: Pain-related outcomes were assessed using surveys with validated scales. Preoperative serum levels of estradiol (E2) and estrone (E1), their 2-, 4- and 16- hydroxylated (OH) and methylated (MeO) derivatives (n=16) were measured by mass spectrometry. We evaluated the associations between estrogen levels and EM anatomic sites, surgical stage, risk of EM, and symptoms reported by women. Spearman correlations established the relationships between circulating steroids. Results: Of the sixteen estrogens profiled, eleven were detected above quantification limits in most individuals. Steroids were positively correlated, except 2-hydroxy 3MeO-E1 (2OH-3MeO-E1). Higher 2OH-3MeO-E1 was linked to an increased risk of EM (Odd ratio (OR)=1.91 (95%CI 1.09-3.34); P=0.025). Ovarian EM cases displayed enhanced 2-hydroxylation with higher 2MeO-E1 and 2OH-E1 levels (P< 0.009). Abdominal, pelvic and back pain symptoms were also linked to higher 2OH-3MeO-E1 levels (OR=1.86; 95%CI 1.06-3.27; P=0.032). Conclusions: The 2-hydroxylation pathway emerges as an unfavorable feature of EM, and is associated with ovarian EM and pain related outcomes.
Language:
English
Keywords:
endometriosis
,
catechol estrogens
,
steroids
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
FFA - Faculty of Pharmacy
MF - Faculty of Medicine
Publication status:
Published
Publication version:
Version of Record
Year:
2023
Number of pages:
Str. 1-13
Numbering:
Vol. 13
PID:
20.500.12556/RUL-143965-7a918e87-ce41-5e9d-5716-8fa65ecab628
UDC:
618.1
ISSN on article:
1664-2392
DOI:
10.3389/fendo.2022.1034614
COBISS.SI-ID:
136322563
Publication date in RUL:
24.01.2023
Views:
572
Downloads:
105
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Title:
Frontiers in endocrinology
Publisher:
Frontiers Research Foundation
ISSN:
1664-2392
COBISS.SI-ID:
3340154
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Secondary language
Language:
Slovenian
Keywords:
endometrioza
,
katehol estrogeni
,
steroidi
Projects
Funder:
Other - Other funder or multiple funders
Funding programme:
Canadian Institutes of Health Research
Project number:
FRN-167269
Funder:
Other - Other funder or multiple funders
Funding programme:
Canada Research Chair
Funder:
ARRS - Slovenian Research Agency
Project number:
J3-1755
Name:
Biokemijski označevalci endometrioze: študije transkriptoma in proteoma
Funder:
EC - European Commission
Funding programme:
H2020
Project number:
101008193
Name:
Translational Research on Endometriosis
Acronym:
TRENDO
Funder:
Other - Other funder or multiple funders
Funding programme:
Fonds de recherche du Québec – Santé, Studentship award
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