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Antibody arrays identified cycle-dependent plasma biomarker candidates of peritoneal endometriosis
ID Pušić Novak, Maja (Author), ID Klančič, Teja (Author), ID Knific, Tamara (Author), ID Vogler, Andrej (Author), ID Schmidt, Ronny (Author), ID Schröder, Christoph (Author), ID Lanišnik-Rižner, Tea (Author)

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Abstract
Endometriosis is an estrogen-dependent inflammatory disease affecting women in their reproductive age. Due to non-specific symptoms, women with endometriosis are often misdiagnosed or are accurately diagnosed only after several years. Diagnosis of peritoneal endometriosis is especially challenging and relies only on laparoscopic surgery. To date, different molecules have been proposed as potential non-invasive biomarkers of endometriosis; however, none have been confirmed as clinically useful. Therefore, this study aimed to discover novel plasma biomarker candidates for peritoneal endometriosis using an antibody array platform. This study included patients with endometriosis-like symptoms characterized by the absence (controls) or presence of peritoneal endometriosis (cases) after laparoscopic surgery and histological evaluation. Patients were further divided into secretory and proliferative groups, according to the phase of their menstrual cycle. Their plasma samples were collected and analyzed on an antibody array platform targeting more than 1350 proteins with over 1820 antibodies. In the proliferative group, the analysis revealed three differential proteins between cases and controls: ITB3, ITA2B2, and ACVL-1. In the secretory group, none of the examined proteins reached the log-fold change (logFC) and significance thresholds simultaneously. The potential of the identified differential proteins as plasma biomarker candidates for peritoneal endometriosis should be evaluated on a larger cohort, and their role in endometriosis should be investigated in further studies.

Language:English
Keywords:peritoneal endometriosis, antibody arrays, biomarkers, integrins, proteomics, discovery, menstrual phase
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:MF - Faculty of Medicine
Publication status:Published
Publication version:Version of Record
Year:2022
Number of pages:16 str.
Numbering:Vol. 12, iss. 6, art. 852
PID:20.500.12556/RUL-143964 This link opens in a new window
UDC:618.1
ISSN on article:2075-4426
DOI:10.3390/jpm12060852 This link opens in a new window
COBISS.SI-ID:109358595 This link opens in a new window
Publication date in RUL:24.01.2023
Views:337
Downloads:62
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Record is a part of a journal

Title:Journal of personalized medicine
Shortened title:J. pers. med.
Publisher:MDPI
ISSN:2075-4426
COBISS.SI-ID:31207641 This link opens in a new window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

Language:Slovenian
Keywords:peritonealna endometrioza, nizi protiteles, biomarkerji

Projects

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Funding programme:Young Researchers

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:J3-1755
Name:Biokemijski označevalci endometrioze: študije transkriptoma in proteoma

Funder:EC - European Commission
Funding programme:H2020
Project number:101008193
Name:Translational Research on Endometriosis
Acronym:TRENDO

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