Scanning electron microscope images of HUVEC cells treated with materials used for processing of orthopaedic and dental Implants
ID Jan, Zala (Author), ID Kononenko, Veno (Author), ID Hočevar, Matej (Author), ID Drobne, Damjana (Author), ID Dolinar, Drago (Author), ID Kocjančič, Boštjan (Author), ID Jenko, Monika (Author), ID Kralj-Iglič, Veronika (Author)

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Use of orthopedic implants (OI) and dental implants (DI) is increasing due to obesity and ageing of the population. To increase the bio-functionality of metallic biomaterials, used for OI and DI, it is important to modify their surface composition, roughness, and structure without altering their mechanical properties. Different materials, such as minerals and inorganic compounds are used for coating OI and DI, however, they may cause response of the cells that are in contact with them in the body. To optimize the use of the materials in implant design, it is of interest to study the effect of the materials on cells. Here we present observations of micron-sized particles of milled Al2O3, TiO2 and hydroxyapatite (HA) on human umbilical vein endothelial cells (HUVEC) by scanning electron microscope. We observed morphological changes of the cells – budding of the cell membrane. Comparing to the control, more cells were detached from the glass they were grown on, indicating possibility of increased cell death or inability of the cells to attach to the surface. Described changes can be due to oxidative stress and inflammatory response of the treated cells.

Keywords:orthopedic implants, inorganic coatings, dental implants, in vitro cell lines, inflammatory response, oxidative stress
Typology:1.06 - Published Scientific Conference Contribution (invited lecture)
Organization:ZF - Faculty of Health Sciences
BF - Biotechnical Faculty
Publication status:Published
Publication version:Version of Record
Number of pages:Str. 97-101
PID:20.500.12556/RUL-143694 This link opens in a new window
DOI:10.55295/PSL.2022.D14 This link opens in a new window
COBISS.SI-ID:122718723 This link opens in a new window
Publication date in RUL:09.01.2023
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Record is a part of a monograph

Title:Socratic lectures : 7th international symposium, Ljubljana, 7. May 2022
Editors:Veronika Kralj-Iglič
Place of publishing:Ljubljana
Publisher:University of Ljubljana Press
COBISS.SI-ID:117944067 This link opens in a new window


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:14.09.2022

Secondary language

Keywords:ortopedski vsadki, anorganski premazi, zobni vsadki, in vitro celične linije, vnetni odziv, oksidativni stres


Funder:ARRS - Slovenian Research Agency
Project number:P3-0388
Name:Mehanizmi varovanja zdravja

Funder:ARRS - Slovenian Research Agency
Project number:J3-3066
Name:Optimizacija s trombociti in zunajceličnimi vezikli bogate avtologne krvne plazme za zdravljenje pooperativnih ran v otorinolaringologiji

Funder:ARRS - Slovenian Research Agency
Project number:J1-9162
Name:Neurotoksičnost ali neuroprotektivnost nanomatrialov: vpliv biokorone

Funder:ARRS - Slovenian Research Agency
Project number:L3-2621
Name:Mehanizmi omajanja endoproteze kolka

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