The pharmacokinetics of levobupivacaine 0.5% after infraorbital or inferior alveolar block in anesthetized dogs

Pavlica, Matic (author), Kržan, Mojca (author), Nemec, Ana (author), Kosjek, Tina (author), Baš, Anže (author), Seliškar, Alenka (author)

Introduction: Data are lacking on the pharmacokinetic profile and safety of levobupivacaine (LB) used for regional anesthesia of the maxilla and mandibles in dogs. Methods: Infraorbital block (n = 10), inferior alveolar block (n = 10) or both infraorbital and inferior alveolar blocks (n = 10) were administered to dogs undergoing dental surgery under isoflurane anesthesia. The dose of LB was calculated as 0.11 ml/kg$^{2/3}$ for the infraorbital block and 0.18 ml/kg$^{2/3}$ for the inferior alveolar block. Blood samples were collected before and immediately after administration of the oral blocks, and 3, 4, 7, 12, 17, 32, 47, 62, 92, and 122 min thereafter. Quantification of LB in plasma was performed by LC-MS/MS. Results and discussion: The results are presented as median and interquartile range. In dogs in which all four quadrants of the oral cavity were desensitized with LB, the C$_{max}$ was 1,335 (1,030–1,929) ng/ml, the T$_{max}$ was 7 (4–9.5) min, and the AUC$_{(0 → 120)}$ was 57,976 (44,954–96,224) ng min/ml. Plasma concentrations of LB were several times lower than the reported toxic concentrations, and no signs of cardiovascular depression or neurotoxicity were observed in any of the dogs, suggesting that the occurrence of severe adverse effects after administration of LB at the doses used in this study is unlikely.

• Language: English
• Keywords: regional anesthesia, levobupivacaine, dexmedetomidine, pharmacology, animal experimentation, dogs, anesthesia
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: VF - Veterinary Faculty; MF - Faculty of Medicine; PEF - Faculty of Education
• Publication status: Published
• Publication version: Version of Record
• Year: 2022
• Number of pages: 7 str.
• Numbering: Vol. 9, art. 1055231
• PID: 20.500.12556/RUL-143343
• UDC: 636.7.09:616-089.5:615.22
• ISSN on article: 2297-1769
• DOI: 10.3389/fvets.2022.1055231
• COBISS.SI-ID: 133962499
• Publication date in RUL: 15.12.2022

Record is a part of a journal

• Title: Frontiers in veterinary science
• Shortened title: Front. vet. sci.
• Publisher: Frontiers Media S.A.
• ISSN: 2297-1769
• COBISS.SI-ID: 3969402

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• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.