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Sinteza oksazolonov, uporaba in biološka aktivnost
ID Pavlič, Jernej (Author), ID Štefane, Bogdan (Mentor) More about this mentor... This link opens in a new window

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Abstract
Oksazoloni so petčlenske heterociklične spojine, v katerih sta kot hetero atoma vključena kisik in dušik. Mesti C-2 in C-4 oksazolonov sta izrednega pomena, saj imata pomembno vlogo v bioloških in farmakoloških interakcijah. Z vezavo različnih substituentov na omenjeni mesti dobimo spojine s številnimi reakcijskimi mesti. N-substituirani oksazoloni prav tako sodelujejo v različnih intermolekularnih reakcijah. So ključni elementi pri sintezi raznolikih farmacevtskih učinkovin in biološko aktivnih spojin. Zaradi teh lastnosti je veliko interesa za to majhno heterociklično strukturo kot ciljno skupino spojin za oceno mnogih farmakoloških učinkov, kot so protimikrobni, pesticidni, inhibitorni, proti raku, proti diabetesu in protivnetni. V tej diplomski nalogi se bom osredotočil na mehanizem tvorbe oksazolona, različne oblike sinteze in farmakološke aktivnosti sintetiziranih spojin.

Language:Slovenian
Keywords:oksazoloni, azlaktoni, sinteza Erlenmeyer-Plöchl, biološko aktivne spojine
Work type:Bachelor thesis/paper
Typology:2.11 - Undergraduate Thesis
Organization:FKKT - Faculty of Chemistry and Chemical Technology
Year:2022
PID:20.500.12556/RUL-141880 This link opens in a new window
COBISS.SI-ID:132900611 This link opens in a new window
Publication date in RUL:10.10.2022
Views:584
Downloads:91
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Secondary language

Language:English
Title:Oxazolone synthesis, use and biological activity
Abstract:
Oxazolones are five-membered heterocyclic compounds with oxygen and nitrogen included as hetero atoms. The C-2 and C-4 positions are vital as they play an important role in biological and pharmacological interactions. Compounds with many reaction sites are obtained by binding different substituents at the mentioned sites. N-substituted oxazolones also participate in various intermolecular reactions. They are vital elements in the synthesis of diverse pharmaceutical agents and biologically active compounds. Due to these properties, there is much interest in this small heterocyclic structure as a target group of compounds to evaluate many pharmacological effects such as antimicrobial, pesticidal, inhibitory, anticancer, antidiabetic and anti-inflammatory. In this thesis, I will focus on the mechanism of oxazolone formation, different forms of synthesis and pharmacological activities of the synthesized compounds.

Keywords:oxazolones, azlactones, Erlenmeyer-Plöchl synthesis, biologically active compounds

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