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The predictive value of oxidative stress index in patients with confirmed SARS-COV-2 infection
ID Osredkar, Joško (Author), ID Pucko, Sara (Author), ID Lukič, Milica (Author), ID Fabjan, Teja (Author), ID Božnar Alič, Elizabeta (Author), ID Kumer, Kristina (Author), ID Martin Rodriguez, Maria (Author), ID Jereb, Matjaž (Author)

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Abstract
Disbalance balance between oxidants and antioxidants is called oxidative stress and could be presented as oxidative stress index (OSI). OSI is determined by the reactive oxygen metabolites (d-ROM test) to assess oxidants and the plasma antioxidant capacity test (PAT test) to measure antioxidants. The aim of the study was to evaluate the predictive value of OSI in the disease COVID-19. d-ROMs results were the highest in the SARS-CoV-2 POSITIVE group (365+/-112), lower in the SARS-CoV-2 NEGATIVE group (314+/-72.4), and the lowest in an INTENSIVE CARE UNIT group (ICU) (277+/-142) U.Carr. PAT test values were the lowest in the SARS-CoV-2 POSITIVE group (2762+/-387), higher in the ICU group (2772 +/-786), and the highest in the SARS-CoV-2 NEGATIVE group (2808+/-470), and are not statistically significantly different (P>0.05), while OSI was: healthy with average value of 49 and the critical ill with average value of 109 (P = 0.016). Cut-offs for predicting ICUs admission was at OSI 62, with 80.0% sensitivity and 68.2% specificity.

Language:English
Keywords:Oxidative stress, SARS-CoV-2, OSI Index
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
MF - Faculty of Medicine
Publication status:Published
Publication version:Version of Record
Year:2022
Number of pages:Str. 564-570
Numbering:Vol. 69, no. 3
PID:20.500.12556/RUL-141738 This link opens in a new window
UDC:616.98:578.834
ISSN on article:1580-3155
DOI:10.17344/acsi.2022.7432 This link opens in a new window
COBISS.SI-ID:124453635 This link opens in a new window
Publication date in RUL:06.10.2022
Views:324
Downloads:74
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Record is a part of a journal

Title:Acta chimica slovenica
Shortened title:Acta chim. slov.
Publisher:Slovensko kemijsko društvo, =Slovenian Chemical Society
ISSN:1580-3155
COBISS.SI-ID:21870085 This link opens in a new window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

Language:Slovenian
Abstract:
Neravnovesje med oksidanti in antioksidanti imenujemo oksidativni stres in ga lahko prikažemo kot indeks oksidativnega stresa (OSI). OSI določimo s testom reaktivnih presnovkov kisika (d-ROM) za oceno oksidantov in testom plazemske antioksidativne kapacitete (PAT) za merjenje antioksidantov. Namen študije je bil oceniti napovedno vrednost OSI pri bolezni COVID-19. Rezultati tasta d-ROM so bili najvišji v skupini SARS-CoV-2 pozitivni (365+/-112), nižji v skupini SARS-CoV-2 negativni (314+/-72,4) in najnižji v skupini kritično bolnih v enoti za intenzivno nego (ICU) (277+/-142) U.Carr. Vrednosti testa PAT so bile najnižje v skupini SARS-CoV-2 pozitivni (2762+/-387), višje v skupini kritično bolnih (2772 +/-786) in najvišje v skupini SARS-CoV-2 negativni (2808 +/-470). Skupine se med sabo statistično značilno ne razlikujejo (P>0,05). OSI se statistično značilno razlikuje med zdravimi s povprečno vrednostjo 49 in kritično bolnimi s povprečno vrednostjo 109 (P = 0,016). Določili smo mejno vrednost za napovedovanje sprejema pacienta v enoto intenzivne nege na osnovi analize OSI, in sicer 62, z 80,0 % občutljivostjo in 68,2 % specifičnostjo.

Keywords:oksidativni stres, SARS-CoV-2, Covid-19

Projects

Funder:ARRS - Slovenian Research Agency
Project number:P3-0124-2020
Name:Metabolni in prirojeni dejavniki reproduktivnega zdravja, porod III

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