Mercury speciation in prenatal exposure in Slovenian and Croatian population - PHIME study
ID Trdin, Ajda (Author), ID Snoj Tratnik, Janja (Author), ID Mazej, Darja (Author), ID Fajon, Vesna (Author), ID Krsnik, Mladen (Author), ID Osredkar, Joško (Author), ID Prpić, Igor (Author), ID Špirić, Zdravko (Author), ID Petrović, Oleg (Author), ID Marc, Janja (Author), ID Neubauer, David (Author), ID Kodrič, Jana (Author), ID Kobal, Alfred Bogomir (Author), ID Barbone, Fabio (Author), ID Falnoga, Ingrid (Author), ID Horvat, Milena (Author)

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In recent years, several studies have addressed the issue of prenatal exposure to methylmercury (MeHg); however, few have actually analysed MeHg blood concentrations. Our study population included mothers and their new-borns from Slovenia (central region; N = 584) and Croatia (coastal region; N = 234). We have measurements of total Hg (THg) and MeHg in maternal hair, maternal peripheral blood, and cord blood. Cord blood Hg concentrations were low to moderate (median THg = 1.84 ng/g and MeHg = 1.69 ng/g). The proportion of THg as MeHg (%MeHg) in maternal and cord blood varied between 4% and 100% (coefficient of variation, CV = 32%) and between 8% and 100% (CV = 20%), respectively. Our data shows that variability of %MeHg was higher at lower blood THg levels. Concentrations of MeHg in maternal blood and cord blood were highly correlated (Rs = 0.943), in the case of inorganic Hg correlation was significant but weaker (Rs = 0.198). MeHg levels in maternal blood and cord blood were positively associated with seafood intake, maternal age, and negatively associated with pre-pregnancy BMI. Additionally, MeHg in maternal blood was positively associated with plasma selenium levels, and cord blood MeHg was negatively associated with parity. The results of multiple linear regression models showed that speciation analysis provides more defined estimation of prenatal exposure in association modelling. Associations between Hg exposure and cognitive performance of children (assessed using Bayley Scales of Infant and Toddler development) adjusted for maternal or child Apolipoprotein E genotypes showed higher model R2 and lower p-values when adjusted for MeHg compared to THg. This study demonstrates that Hg speciation improves the association between exposure and possible negative health effects.

Keywords:ekologija, varstvo naravnih virov, ogrožanje okolja in njegovo varstvo
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Publication version:Version of Record
Publication date:01.01.2019
Number of pages:Str. 108627-1-108627-10
Numbering:art. 108627, Vol. 177
PID:20.500.12556/RUL-141294 This link opens in a new window
ISSN on article:0013-9351
DOI:10.1016/j.envres.2019.108627 This link opens in a new window
COBISS.SI-ID:32549415 This link opens in a new window
Publication date in RUL:28.09.2022
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Record is a part of a journal

Title:Environmental research. multidisciplinary journal of environmental sciences, ecology, and public health
Shortened title:Environ. res.
Publisher:Academic Press
COBISS.SI-ID:3951911 This link opens in a new window


License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.


Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:J7-9400-2018
Name:Nevropsihološke disfunkcije, ki jih povzroča nizka stopnja izpostavljenosti izbranim onesnaževalom iz okolja pri občutljivi populaciji - NEURODYS

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:P1-0143-2015
Name:Kroženje snovi v okolju, snovna bilanca in modeliranje okoljskih procesov ter ocena tveganja

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