Trace elements and APOE polymorphisms in pregnant women and their new-borns

Trdin, Ajda (author), Snoj Tratnik, Janja (author), Stajnko, Anja (author), Marc, Janja (author), Mazej, Darja (author), Sešek-Briški, Alenka (author), Kastelec, Damijana (author), Prpić, Igor (author), Petrović, Oleg (author), Špirić, Igor (author), Horvat, Milena (author), Falnoga, Ingrid (author)

We investigated the relationship between lipid binding glycoprotein apolipoprotein E (apoE; gene APOE) polymorphisms (%4 allele carriers versus no carriers = 4+/4%) and trace elements (TEs) (e.g., (methyl)mercury, arsenic, lead, cadmium, selenium, manganese, copper, and zinc) in mothers (N = 223) and their new-borns (N = 213) exposed to potentially toxic metal(loid)s from seafood consumption. The apoE isoform encoded by the %4 allele is believed to have beneficial effects in early life but represents a risk factor for age-associated diseases. Under certain conditions %4 carriers are more susceptible to oxidative stress and metal(loid) toxicity. DNA from Croatian pregnant women (N = 223, third trimester) and their new-borns (N = 176), was genotyped for APOE by TaqMan% SNP assay % rs429358 and rs7412. Seafood intake data and TE levels in maternal urine, milk, hair, peripheral venous blood, mixed cord blood, and new-borns% urine were available from previous studies. We compared TEs between %4+ and %4% carriers using Mann-Whitney U tests and applied multiple linear regression models to analyse the TE%s dependence on the presence of allele %4 (genotypes 3/4,4/4) in combination with other explanatory variables. We identified 17% (n = 37) and 20% (n = 35) %4 allele carriers in mothers and new-borns, respectively. The Mann-Whitney U test showed that mothers with the %4 allele had significantly higher mean levels of (methyl)mercury in peripheral venous blood, cord blood, and hair; arsenic in urine and cord blood; and selenium in peripheral venous blood and plasma. However, taking confounders into account, only the maternal plasma selenium remained statistically significant in the linear regression models (%4 carriers vs non-carriers: 62.6 vs 54.9 ng/mL, p < 0.001). Literature suggestions of possible %4 allele impact on Hg levels were not observed, while superior selenium status observed in healthy pregnant women carrying allele %4 could be linked to the proposed APOE %4 beneficial effects early in life

• Language: English
• Keywords: ε4 allele, pregnancy, selenium, mercury, trace elements, apolipoprotein E polymorphism
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FFA - Faculty of Pharmacy; BF - Biotechnical Faculty
• Publication version: Version of Record
• Publication date: 01.01.2020
• Year: 2020
• Number of pages: Str. 105626-1-105626-13
• Numbering: Vol. 143, art. 105626
• PID: 20.500.12556/RUL-141284
• UDC: 543
• ISSN on article: 0160-4120
• DOI: 10.1016/j.envint.2020.105626
• COBISS.SI-ID: 24060675
• Publication date in RUL: 28.09.2022

Record is a part of a journal

• Title: Environment international
• Shortened title: Environ. int.
• Publisher: Elsevier
• ISSN: 0160-4120
• COBISS.SI-ID: 25403136

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: kemija okolja

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: J7-9400-2018
• Name: Nevropsihološke disfunkcije, ki jih povzroča nizka stopnja izpostavljenosti izbranim onesnaževalom iz okolja pri občutljivi populaciji - NEURODYS

• Funder: ARRS - Slovenian Research Agency
• Project number: P1-0143-2020
• Name: Kroženje snovi v okolju, snovna bilanca in modeliranje okoljskih procesov ter ocena tveganja