Reproductive outcomes after laparoscopic surgery in infertile women affected by ovarian endometriomas, with or without in vitro fertilisation : results from the SAFE (surgery and ART for endometriomas) trial

Ban, Helena (author), Vrtačnik-Bokal, Eda (author), Štimpfel, Martin (author), Divjak Budihna, Teja (author), Gulino, Ferdinando Antonio (author), Garzon, Simone (author), Ghezzi, Fabio (author), Alkatout, Ibrahim (author), Gitas, Georgios (author), Laganà, Antonio Simone (author)

We performed a retrospective cohort study, namely “Surgery and ART for Endometriomas” (SAFE) trial (Clinical Trial ID: NCT03717870), including women who underwent laparoscopic cystectomy for endometrioma before first IVF and compared their reproductive outcomes with the ones of women without endometriosis and with unexplained infertility, tubal factor or male factor infertility. We found that women who underwent previous laparoscopic cystectomy for endometrioma had higher FSH and LH levels between the 2nd and 5th day of the cycle before IVF, required higher doses of gonadotrophins for ovarian stimulation and had a lower number of retrieved oocytes compared with other types of infertility. Nevertheless, pregnancy and delivery rates remain comparable to other causes of infertility. In addition, differences in ovarian stimulation parameters between endometriosis and other types of infertility lost significance with the increase of women’s age. These pieces of information can be considered useful to make adequate counselling about reproductive outcomes for infertile women with ovarian endometriomas and allow a proper decision-making approach shared with the patient.

• Language: English
• Keywords: endometriosis, laparoscopic surgery, in vitro fertilisation, reproductive outcomes
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2022
• Number of pages: Str. 1293-1300
• Numbering: Vol. 42, no. 5
• PID: 20.500.12556/RUL-141233
• UDC: 618.1
• ISSN on article: 0144-3615
• DOI: 10.1080/01443615.2021.1959536
• COBISS.SI-ID: 95982595
• Publication date in RUL: 26.09.2022

Record is a part of a journal

• Title: Journal of obstetrics and gynaecology
• Shortened title: J. obstet. gynaecol.
• Publisher: Taylor & Francis
• ISSN: 0144-3615
• COBISS.SI-ID: 738325

Licences

• License: CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
• Link: http://creativecommons.org/licenses/by-nc-nd/4.0/
• Description: The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

Secondary language

• Language: Slovenian
• Keywords: ginekologija, laparoskopska kirurgija, neplodnost, endometrioza