Low oral bioavailability as a consequence of the low solubility of active compounds in water poses an increasing challenge. One of the approaches how to improve the dissolution and thus the bioavailability of poorly water-soluble active compounds is also the production of various lipid-based formulations. The latter can be in the form of emulsions or melts. Different approaches can be used for conversion to a solid state, such as (micro)encapsulation, direct adsorption on mesoporous carriers, granulation, and others.
The purpose of the master's thesis was to produce a solid formulation of poorly water-soluble antioxidants of resveratrol and coenzyme Q10 which will disperse rapidly in an aqueous medium and improve the solubility of embedded antioxidants. According to the biopharmaceutical classification system, both resveratrol and coenzyme Q10 are classified in II. class because both have poor water solubility and good permeability. To improve the dispersibility of both antioxidants in the aqueous phase, we used the emulsification method, namely resveratrol was incorporated into oil-in-water emulsions which contained medium- (Captex 355) or long-chain (olive oil) triglyceride as the oil phase. Because of the low melting point of coenzyme Q10, the melt of coenzyme Q10 was used as the oil phase in its case. Tween 80 proved to be the best emulsifier in both systems.
All emulsions were converted to fast dispersible powders using mesoporous Syloid 244 FP as a solid support. Resveratrol emulsions were solidified by spray drying. In coenzyme Q10 formulations, we used also manual melt granulation and melt granulation in a high-shear mixer.
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