Liposomes are vesicular structures capable of entrapping both
hydrophobic and hydrophilic compounds and can therefore be used as carriers
for the delivery of drugs and macromolecules into human and animal bodies.
Liposomes can be made from natural and synthetic phospholipids. In this study,
we dealt with a new liposomal formulation without the use of pharmacologically
unwanted organic solvents that are harmful to the environment in the
preparation, we used two different lipids: egg lecithin and liquid sunflower
lecithin, and mixtures of glycerol and water as lipid solvents in different weight
ratios. We investigated the size of the vesicles in the prepared
lecithin/glycerol/water suspensions using the dynamic light scattering method.
We were interested in the effect of temperature on the hydrodynamic radius of
the vesicles and whether the addition of CBD oil or the aqueous solution of
lysozyme affects the size of the vesicles. We confirmed the hypothesis that the
size of the vesicles depends on the ratio between lecithin, glycerol and water. If
there is more glycerol in the suspension, larger vesicles form. Smaller vesicles
form when CBD oil is added, however larger ones do so when lysozyme is
present.
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