Nowadays many studies are focused on the research of metal complexes with dipicolinic acid derivatives. The interaction of metal ions with ligands is recognized as an important area of research on diabetes treatments. The main goal of this thesis was the optimization of precursors of organic ligands synthesis in which I wanted to obtain a product with the highest possible yield and purity. As part of the experimental work the compound dimethyl pyridine-2,6-dicarboxylate was synthesized from dipicolinic acid. The synthesized acid was then used as a starting compound for the synthesis of 6-methoxycarbonylpyridine-2-carboxylic acid, which was the desired product of the synthesis. Seventeen reactions were performed to optimize the synthesis procedure. The initial recipe was obtained from literature where gradual changes were introduced. During the optimization process I changed the mass of the starting compound, the volume of the solvent, the type and concentration of the base and the mass ratio between the reactants when compared to the starting recipe. The reactions were performed at different temperatures and mixing times. I characterized each obtained product by 1H NMR spectroscopy and checked its purity. I managed to optimize the synthesis procedure in which I obtained reproducible results with yields ranging between 79 and 99%. The synthesized product was of high purity and is useful for further syntheses of ligands suitable for binding to metal ions.
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