Protein release from nanocellulose and alginate hydrogels : the study of adsorption and desorption kinetics

Kopač, Tilen (author), Krajnc, Matjaž (author), Ručigaj, Aleš (author)

This work presents a study of the lysozyme release from crosslinked TEMPO nanocellulose (TOCNF) and alginate (ALG) hydrogels in a medium with different ionic strength and temperature. The main objective is to develop a mathematical model for a detailed study of the concurrent action of diffusion mechanism and adsorption/desorption kinetics. Model fit parameters provide important information about the initial (maximum) adsorption rate and its deceleration with increasing ionic strength of the release medium. Similarly, the initial (minimum) desorption rate and its acceleration with increasing salt concentration can be determined. The model leads us to the conclusion that the initial adsorption rate is higher in the case of TOCNF, but due to fewer electrostatic interactions and morphology as well as topography of the surface, it decreases to a negligible value much faster than in the case of ALG, where the diffusion process becomes dominant.

• Language: English
• Keywords: lysozyme, adsorption, TEMPO nanocellulose, alginate, controlled protein release, mathematical modeling
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Publication status: Published
• Publication version: Version of Record
• Year: 2022
• Number of pages: 10 str.
• Numbering: Vol. 217, art. 112677
• PID: 20.500.12556/RUL-137871
• UDC: 678:544.4
• ISSN on article: 0927-7765
• DOI: 10.1016/j.colsurfb.2022.112677
• COBISS.SI-ID: 113668355
• Publication date in RUL: 05.07.2022

Record is a part of a journal

• Title: Colloids and surfaces : Biointerfaces
• Shortened title: Colloids surf., B Biointerfaces
• Publisher: Elsevier
• ISSN: 0927-7765
• COBISS.SI-ID: 15329029

Licences

• License: CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
• Link: http://creativecommons.org/licenses/by-nc-nd/4.0/
• Description: The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

Secondary language

• Language: Slovenian
• Keywords: lizocim, adsorpcija, TEMPO nanoceluloza, alginat, kontrolirano sproščanje proteina, matematično modeliranje, polimeri

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P2-0191
• Name: Kemijsko inženirstvo