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Protein release from nanocellulose and alginate hydrogels : the study of adsorption and desorption kinetics
ID Kopač, Tilen (Author), ID Krajnc, Matjaž (Author), ID Ručigaj, Aleš (Author)

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Abstract
This work presents a study of the lysozyme release from crosslinked TEMPO nanocellulose (TOCNF) and alginate (ALG) hydrogels in a medium with different ionic strength and temperature. The main objective is to develop a mathematical model for a detailed study of the concurrent action of diffusion mechanism and adsorption/desorption kinetics. Model fit parameters provide important information about the initial (maximum) adsorption rate and its deceleration with increasing ionic strength of the release medium. Similarly, the initial (minimum) desorption rate and its acceleration with increasing salt concentration can be determined. The model leads us to the conclusion that the initial adsorption rate is higher in the case of TOCNF, but due to fewer electrostatic interactions and morphology as well as topography of the surface, it decreases to a negligible value much faster than in the case of ALG, where the diffusion process becomes dominant.

Language:English
Keywords:lysozyme, adsorption, TEMPO nanocellulose, alginate, controlled protein release, mathematical modeling
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:FKKT - Faculty of Chemistry and Chemical Technology
Publication status:Published
Publication version:Version of Record
Year:2022
Number of pages:10 str.
Numbering:Vol. 217, art. 112677
PID:20.500.12556/RUL-137871 This link opens in a new window
UDC:678:544.4
ISSN on article:0927-7765
DOI:10.1016/j.colsurfb.2022.112677 This link opens in a new window
COBISS.SI-ID:113668355 This link opens in a new window
Publication date in RUL:05.07.2022
Views:519
Downloads:132
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Record is a part of a journal

Title:Colloids and surfaces. B, Biointerfaces
Shortened title:Colloids surf., B, Biointerfaces
Publisher:Elsevier
ISSN:0927-7765
COBISS.SI-ID:15329029 This link opens in a new window

Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

Secondary language

Language:Slovenian
Keywords:lizocim, adsorpcija, TEMPO nanoceluloza, alginat, kontrolirano sproščanje proteina, matematično modeliranje, polimeri

Projects

Funder:ARRS - Slovenian Research Agency
Project number:P2-0191
Name:Kemijsko inženirstvo

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