The role of vitamin A in retinal diseases

Sajovic, Jana (author), Meglič, Andrej (author), Glavač, Damjan (author), Markelj, Špela (author), Hawlina, Marko (author), Fakin, Ana (author)

Vitamin A is an essential fat-soluble vitamin that occurs in various chemical forms. It is essential for several physiological processes. Either hyper- or hypovitaminosis can be harmful. One of the most important vitamin A functions is its involvement in visual phototransduction, where it serves as the crucial part of photopigment, the first molecule in the process of transforming photons of light into electrical signals. In this process, large quantities of vitamin A in the form of 11-cis-retinal are being isomerized to all-trans-retinal and then quickly recycled back to 11-cis-retinal. Complex machinery of transporters and enzymes is involved in this process (i.e., the visual cycle). Any fault in the machinery may not only reduce the efficiency of visual detection but also cause the accumulation of toxic chemicals in the retina. This review provides a comprehensive overview of diseases that are directly or indirectly connected with vitamin A pathways in the retina. It includes the pathophysiological background and clinical presentation of each disease and summarizes the already existing therapeutic and prospective interventions.

• Language: English
• Keywords: vitamin A, retinal diseases, ABCA4, visual cycle, RHO, RDH5, RDH12, treatment
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2022
• Number of pages: 27 str.
• Numbering: Vol. 23, iss. 3, art. 1014
• PID: 20.500.12556/RUL-137124
• UDC: 617.7
• ISSN on article: 1422-0067
• DOI: 10.3390/ijms23031014
• COBISS.SI-ID: 97200131
• Publication date in RUL: 01.06.2022

Record is a part of a journal

• Title: International journal of molecular sciences
• Shortened title: Int. j. mol. sci.
• Publisher: MDPI
• ISSN: 1422-0067
• COBISS.SI-ID: 2779162

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 01.02.2022

Secondary language

• Language: Slovenian
• Keywords: vitamin A, bolezni mrežnice, ABCA4

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: J3-1750
• Name: Priprava pogojev za gensko zdravljenje dednih očesnih bolezni