LPA genotypes and haplotypes are associated with lipoprotein(a) levels but not arterial wall properties in stable post-coronary event patients with very high lipoprotein(a) levels

Rehberger Likozar, Andreja (author), Blinc, Aleš (author), Trebušak Podkrajšek, Katarina (author), Šebeštjen, Miran (author)

Lipoprotein(a) [Lp(a)] levels are an independent risk factor for coronary artery disease (CAD). Two single-nucleotide polymorphisms (rs10455872, rs3798220) and number of KIV-2 repeats in the gene encoding Lp(a) (LPA) are associated with Lp(a) and CAD. Our aim was to investigate whether in patients with stable CAD and high Lp(a) levels these genetic variants are associated with increased Lp(a) and arterial wall properties. Blood samples underwent biochemical and genetic analyses. Ultrasound measurements for the functional and morphological properties of arterial wall were performed. Genotypes of rs10455872 and haplotypes AT and GT showed significant association with Lp(a) levels. Patients with GG showed significantly higher Lp(a) levels compared with those with AG genotype (2180 vs. 1391 mg/L, p = 0.045). Patients with no AT haplotype had significantly higher Lp(a) compared to carriers of one AT haplotype (2158 vs. 1478 mg/L, p = 0.023) or two AT haplotypes (2158 vs. 1487 mg/L, p = 0.044). There were no significant associations with the properties of the arterial wall. Lp(a) levels significantly correlated also with number of KIV-2 repeats (r = −0.601; p < 0.0001). In our patients, these two LPA polymorphisms and number of KIV-2 repeats are associated with Lp(a), but not arterial wall properties.

• Language: English
• Keywords: coronary artery disease, LPA genotypes, haplotypes, lipoprotein(a), rs10455872, rs3798220, KIV-2 repeats
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2021
• Number of pages: 15 str.
• Numbering: Vol. 8, iss. 12, art. 181
• PID: 20.500.12556/RUL-136569
• UDC: 616.1
• ISSN on article: 2308-3425
• DOI: 10.3390/jcdd8120181
• COBISS.SI-ID: 89456643
• Publication date in RUL: 11.05.2022

Record is a part of a journal

• Title: Journal of cardiovascular development and disease
• Shortened title: J. cardiovasc. dev. dis.
• Publisher: MDPI AG
• ISSN: 2308-3425
• COBISS.SI-ID: 523193113

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 13.12.2021

Secondary language

• Language: Slovenian
• Keywords: bolezen koronarnih arterij, genotipi LPA, haplotipi