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Sensing and responding to hypersaline conditions and the HOG signal transduction pathway in fungi isolated from hypersaline environments : Hortaea werneckii and Wallemia ichthyophaga
ID Plemenitaš, Ana (Author)

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Abstract
Sensing and responding to changes in NaCl concentration in hypersaline environments is vital for cell survival. In this paper, we identified and characterized key components of the high-osmolarity glycerol (HOG) signal transduction pathway, which is crucial in sensing hypersaline conditions in the extremely halotolerant black yeast Hortaea werneckii and in the obligate halophilic fungus Wallemia ichthyophaga. Both organisms were isolated from solar salterns, their predominating ecological niche. The identified components included homologous proteins of both branches involved in sensing high osmolarity (SHO1 and SLN1) and the homologues of mitogen-activated protein kinase module (MAPKKK Ste11, MAPKK Pbs2, and MAPK Hog1). Functional complementation of the identified gene products in S. cerevisiae mutant strains revealed some of their functions. Structural protein analysis demonstrated important structural differences in the HOG pathway components between halotolerant/halophilic fungi isolated from solar salterns, salt-sensitive S. cerevisiae, the extremely salt-tolerant H. werneckii, and halophilic W. ichthyophaga. Known and novel gene targets of MAP kinase Hog1 were uncovered particularly in halotolerant H. werneckii. Molecular studies of many salt-responsive proteins confirm unique and novel mechanisms of adaptation to changes in salt concentration.

Language:English
Keywords:halotolerant/halophilic fungi, Hortaea werneckii, Wallemia ichthyophaga, HOG, signal transduction pathway
Work type:Article
Typology:1.02 - Review Article
Organization:MF - Faculty of Medicine
Publication status:Published
Publication version:Version of Record
Year:2021
Number of pages:13 str.
Numbering:Vol. 7, iss. 11, art. 988
PID:20.500.12556/RUL-136365 This link opens in a new window
UDC:577
ISSN on article:2309-608X
DOI:10.3390/jof7110988 This link opens in a new window
COBISS.SI-ID:86840579 This link opens in a new window
Publication date in RUL:26.04.2022
Views:471
Downloads:84
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Record is a part of a journal

Title:Journal of Fungi
Shortened title:J. Fungi
Publisher:MDPI
ISSN:2309-608X
COBISS.SI-ID:525300761 This link opens in a new window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:19.11.2021

Secondary language

Language:Slovenian
Keywords:halotolerantne/halofilne glive, Hortaea werneckii, Wallemia ichthyophaga

Projects

Funder:ARRS - Slovenian Research Agency
Project number:P1-0170
Name:Molekulski mehanizmi uravnavanja celičnih procesov v povezavi z nekaterimi boleznimi pri človeku

Funder:ARRS - Slovenian Research Agency
Funding programme:Young Researchers

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