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Plectin in the central nervous system and a putative role in brain astrocytes
ID Potokar, Maja (Author), ID Jorgačevski, Jernej (Author)

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Abstract
Plectin, a high-molecular-mass cytolinker, is abundantly expressed in the central nervous system (CNS). Currently, a limited amount of data about plectin in the CNS prevents us from seeing the complete picture of how plectin affects the functioning of the CNS as a whole. Yet, by analogy to its role in other tissues, it is anticipated that, in the CNS, plectin also functions as the key cytoskeleton interlinking molecule. Thus, it is likely involved in signalling processes, thereby affecting numerous fundamental functions in the brain and spinal cord. Versatile direct and indirect interactions of plectin with cytoskeletal filaments and enzymes in the cells of the CNS in normal physiological and in pathologic conditions remain to be fully addressed. Several pathologies of the CNS related to plectin have been discovered in patients with plectinopathies. However, in view of plectin as an integrator of a cohesive mesh of cellular proteins, it is important that the role of plectin is also considered in other CNS pathologies. This review summarizes the current knowledge of plectin in the CNS, focusing on plectin isoforms that have been detected in the CNS, along with its expression profile and distribution alongside diverse cytoskeleton filaments in CNS cell types. Considering that the bidirectional communication between neurons and glial cells, especially astrocytes, is crucial for proper functioning of the CNS, we place particular emphasis on the known roles of plectin in neurons, and we propose possible roles of plectin in astrocytes.

Language:English
Keywords:plectin, central nervous system, astrocytes, glia, neurons, intermediate filaments, microtubules, actin filaments, cytolinker proteins
Work type:Article
Typology:1.02 - Review Article
Organization:MF - Faculty of Medicine
Publication status:Published
Publication version:Version of Record
Year:2021
Number of pages:17 str.
Numbering:Vol. 10, iss. 9, art. 2353
PID:20.500.12556/RUL-136141 This link opens in a new window
UDC:616-092
ISSN on article:2073-4409
DOI:10.3390/cells10092353 This link opens in a new window
COBISS.SI-ID:76345603 This link opens in a new window
Publication date in RUL:13.04.2022
Views:939
Downloads:74
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Record is a part of a journal

Title:Cells
Shortened title:Cells
Publisher:MDPI
ISSN:2073-4409
COBISS.SI-ID:519958809 This link opens in a new window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:08.09.2021

Secondary language

Language:Slovenian
Keywords:plektin, centralni živčni sistem, astrociti

Projects

Funder:ARRS - Slovenian Research Agency
Project number:P3-0310
Name:Celična fiziologija

Funder:ARRS - Slovenian Research Agency
Project number:J3-9266
Name:Uravnavanje fuzijske pore in motnje skladiščenja v lizosomih

Funder:ARRS - Slovenian Research Agency
Project number:J3-7605
Name:Nanofiziologija eksocitoze v zdravih in bolezenskih razmerah

Funder:Other - Other funder or multiple funders
Funding programme:COST
Project number:CA15214
Acronym:EuroCellNet

Funder:Other - Other funder or multiple funders
Funding programme:CipKeBip

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