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Serum bilirubin levels in overweight and obese individuals : the importance of anti-inflammatory and antioxidant responses
ID
Žiberna, Lovro
(
Author
),
ID
Jenko Pražnikar, Zala
(
Author
),
ID
Petelin, Ana
(
Author
)
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MD5: F585262C180AA000E14C4288EF6ADBE0
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https://www.mdpi.com/2076-3921/10/9/1352
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Abstract
Obesity is a chronic condition involving low-grade inflammation and increased oxidative stress; thus, obese and overweight people have lower values of serum bilirubin. Essentially, bilirubin is a potent endogenous antioxidant molecule with anti-inflammatory, immunomodulatory, antithrombotic, and endocrine properties. This review paper presents the interplay betweeen obesity-related pathological processes and bilirubin, with a focus on adipose tissue and adipokines. We discuss potential strategies to mildly increase serum bilirubin levels in obese patients as an adjunctive therapeutic approach.
Language:
English
Keywords:
adipokines
,
antioxidant
,
anti-inflammatory
,
bilirubin
,
obesity
,
overweight
Work type:
Article
Typology:
1.02 - Review Article
Organization:
MF - Faculty of Medicine
Publication status:
Published
Publication version:
Version of Record
Year:
2021
Number of pages:
16 str.
Numbering:
Vol. 10, iss. 9, art. 1352
PID:
20.500.12556/RUL-136091
UDC:
613.25
ISSN on article:
2076-3921
DOI:
10.3390/antiox10091352
COBISS.SI-ID:
76178947
Publication date in RUL:
12.04.2022
Views:
755
Downloads:
116
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Record is a part of a journal
Title:
Antioxidants
Shortened title:
Antioxidants
Publisher:
MDPI
ISSN:
2076-3921
COBISS.SI-ID:
522976025
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:
01.09.2021
Secondary language
Language:
Slovenian
Keywords:
adipokini
,
antioksidanti
,
protivnetje
,
bilirubin
,
debelost
,
prekomerna telesna masa
Projects
Funder:
ARRS - Slovenian Research Agency
Project number:
J3-8209
Name:
Bilirubin kot zaščitni dejavnik pred razvojem kroničnih degenerativnih bolezni: serumski biomarker in možnosti farmakološke modulacije
Funder:
ARRS - Slovenian Research Agency
Project number:
P1-0386
Name:
Varstvena biologija od molekul do ekosistema
Funder:
ARRS - Slovenian Research Agency
Project number:
P3-0067
Name:
Farmakologija in farmakogenomika
Funder:
Other - Other funder or multiple funders
Funding programme:
University of Primorska, Faculty of Health Sciences
Name:
A Multidisciplinary Approach in the Treatment of Obesity
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