Serum bilirubin levels in overweight and obese individuals : the importance of anti-inflammatory and antioxidant responses

Žiberna, Lovro (author), Jenko Pražnikar, Zala (author), Petelin, Ana (author)

Obesity is a chronic condition involving low-grade inflammation and increased oxidative stress; thus, obese and overweight people have lower values of serum bilirubin. Essentially, bilirubin is a potent endogenous antioxidant molecule with anti-inflammatory, immunomodulatory, antithrombotic, and endocrine properties. This review paper presents the interplay betweeen obesity-related pathological processes and bilirubin, with a focus on adipose tissue and adipokines. We discuss potential strategies to mildly increase serum bilirubin levels in obese patients as an adjunctive therapeutic approach.

• Language: English
• Keywords: adipokines, antioxidant, anti-inflammatory, bilirubin, obesity, overweight
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2021
• Number of pages: 16 str.
• Numbering: Vol. 10, iss. 9, art. 1352
• PID: 20.500.12556/RUL-136091
• UDC: 613.25
• ISSN on article: 2076-3921
• DOI: 10.3390/antiox10091352
• COBISS.SI-ID: 76178947
• Publication date in RUL: 12.04.2022

Record is a part of a journal

• Title: Antioxidants
• Shortened title: Antioxidants
• Publisher: MDPI
• ISSN: 2076-3921
• COBISS.SI-ID: 522976025

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 01.09.2021

Secondary language

• Language: Slovenian
• Keywords: adipokini, antioksidanti, protivnetje, bilirubin, debelost, prekomerna telesna masa