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A review and evaluation of the data supporting internal use of Helichrysum italicum
ID
Kramberger, Katja
(
Author
),
ID
Kenig, Saša
(
Author
),
ID
Jenko Pražnikar, Zala
(
Author
),
ID
Kočevar Glavač, Nina
(
Author
),
ID
Barlič-Maganja, Darja
(
Author
)
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https://www.mdpi.com/2223-7747/10/8/1738
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Abstract
Helichrysum italicum is a Mediterranean plant with various pharmacological activities. Despite extensive reports on the bioactivity of the plant, its clinically studied applications have not yet been reviewed. The aim of our study was to gather information on the internal use of H. italicum and its bioactive constituents to determine its efficacy and safety for human use. We reviewed research articles that have not been previously presented in this context and analyzed relevant clinical studies with H. italicum. Cochranelibrary.com revealed six eligible clinical trials with H. italicum that examined indications for pain management, cough, and mental exhaustion. Although the efficacy of H. italicum has been demonstrated both in in vitro tests and in humans, it is difficult to attribute results from clinical trials to H. italicum alone, as it has usually not been tested as the sole component. On the other hand, clinical trials provide positive information on the safety profile since no adverse effects have been reported. We conclude that H. italicum is safe to use internally, while new clinical studies with H. italicum as a single component are needed to prove its efficacy. Based on the recent trend in H. italicum research, further studies are to be expected.
Language:
English
Keywords:
Helichrysum italicum
,
biological activity
,
internal use
,
clinical studies
Work type:
Article
Typology:
1.02 - Review Article
Organization:
MF - Faculty of Medicine
FFA - Faculty of Pharmacy
Publication status:
Published
Publication version:
Version of Record
Year:
2021
Number of pages:
17 str.
Numbering:
Vol. 10, iss. 8, art. 1738
PID:
20.500.12556/RUL-136081
UDC:
633.812:613.2
ISSN on article:
2223-7747
DOI:
10.3390/plants10081738
COBISS.SI-ID:
76122627
Publication date in RUL:
11.04.2022
Views:
621
Downloads:
106
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Record is a part of a journal
Title:
Plants
Shortened title:
Plants
Publisher:
MDPI
ISSN:
2223-7747
COBISS.SI-ID:
523345433
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:
23.08.2021
Secondary language
Language:
Slovenian
Keywords:
Helichrysum italicum
,
biološka aktivnost
,
klinične študije
Projects
Funder:
ARRS - Slovenian Research Agency
Project number:
P1-0386
Name:
Varstvena biologija od molekul do ekosistema
Funder:
ARRS - Slovenian Research Agency
Funding programme:
Young researchers
Project number:
1000-18-1988
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