A review and evaluation of the data supporting internal use of Helichrysum italicum

Kramberger, Katja (author), Kenig, Saša (author), Jenko Pražnikar, Zala (author), Kočevar Glavač, Nina (author), Barlič-Maganja, Darja (author)

Helichrysum italicum is a Mediterranean plant with various pharmacological activities. Despite extensive reports on the bioactivity of the plant, its clinically studied applications have not yet been reviewed. The aim of our study was to gather information on the internal use of H. italicum and its bioactive constituents to determine its efficacy and safety for human use. We reviewed research articles that have not been previously presented in this context and analyzed relevant clinical studies with H. italicum. Cochranelibrary.com revealed six eligible clinical trials with H. italicum that examined indications for pain management, cough, and mental exhaustion. Although the efficacy of H. italicum has been demonstrated both in in vitro tests and in humans, it is difficult to attribute results from clinical trials to H. italicum alone, as it has usually not been tested as the sole component. On the other hand, clinical trials provide positive information on the safety profile since no adverse effects have been reported. We conclude that H. italicum is safe to use internally, while new clinical studies with H. italicum as a single component are needed to prove its efficacy. Based on the recent trend in H. italicum research, further studies are to be expected.

• Language: English
• Keywords: Helichrysum italicum, biological activity, internal use, clinical studies
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine; FFA - Faculty of Pharmacy
• Publication status: Published
• Publication version: Version of Record
• Year: 2021
• Number of pages: 17 str.
• Numbering: Vol. 10, iss. 8, art. 1738
• PID: 20.500.12556/RUL-136081
• UDC: 633.812:613.2
• ISSN on article: 2223-7747
• DOI: 10.3390/plants10081738
• COBISS.SI-ID: 76122627
• Publication date in RUL: 11.04.2022

Record is a part of a journal

• Title: Plants
• Shortened title: Plants
• Publisher: MDPI
• ISSN: 2223-7747
• COBISS.SI-ID: 523345433

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 23.08.2021

Secondary language

• Language: Slovenian
• Keywords: Helichrysum italicum, biološka aktivnost, klinične študije

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P1-0386
• Name: Varstvena biologija od molekul do ekosistema

• Funder: ARRS - Slovenian Research Agency
• Funding programme: Young researchers
• Project number: 1000-18-1988