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Non-alcoholic fatty liver disease in children
ID Brecelj, Jernej (Author), ID Orel, Rok (Author)

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Abstract
Background and Objectives: The prevalence of pediatric non-alcoholic fatty liver disease is increasing. A lot of new data are published regularly. Materials and Methods: Original clinical studies, review articles, and guidelines in children were searched for and the most relevant included in this review. Results: A total of 138 retrieved papers were classified into pathogenesis, epidemiology, diagnosis, and treatment. Pathogenesis is currently explained with the "multi hit hypothesis", with complex interactions of genetic and environmental factors which trigger inflammation in steatotic liver. The prevalence is rising. A diagnosis can be made with laboratory tests, imaging, and liver biopsy after the exclusion of other causes of liver steatosis. The mainstay of treatment is lifestyle modification consisting of dietary intervention and increased physical activity. The progression to liver cirrhosis can occur even in children. Conclusions: Non-alcoholic fatty liver disease in children is a part of a metabolic syndrome in the majority of patients. Due to its complex etiology and high prevalence, multidisciplinary teams, together with public health professionals, should be involved in its treatment.

Language:English
Keywords:pediatric fatty liver disease, diet, lifestyle modification, obesity, physical activity
Work type:Article (dk_c)
Typology:1.02 - Review Article
Organization:MF - Faculty of Medicine
Year:2021
Publication status in journal:Published
Article version:Publisher's version of article
Number of pages:15 str.
Numbering:Vol. 57, iss. 7, art. 719
UDC:616-053.2
ISSN on article:1648-9144
DOI:10.3390/medicina57070719 This link opens in a new window
COBISS.SI-ID:81204483 This link opens in a new window
Publication date in RUL:06.04.2022
Views:97
Downloads:33
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Record is a part of a journal

Title:Medicina
Publisher:MDPI
ISSN:1648-9144
COBISS.SI-ID:6754623 This link opens in a new window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:16.07.2021

Secondary language

Language:Slovenian
Keywords:otroška maščobna jetrna bolezen, prehrana, sprememba življenjskega sloga

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