Therapeutic potential of polyphenols in amyotrophic lateral sclerosis and frontotemporal dementia

Novak, Valentina (author), Rogelj, Boris (author), Župunski, Vera (author)

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are severe neurodegenerative disorders that belong to a common disease spectrum. The molecular and cellular aetiology of the spectrum is a highly complex encompassing dysfunction in many processes, including mitochondrial dysfunction and oxidative stress. There is a paucity of treatment options aside from therapies with subtle effects on the post diagnostic lifespan and symptom management. This presents great interest and necessity for the discovery and development of new compounds and therapies with beneficial effects on the disease. Polyphenols are secondary metabolites found in plant-based foods and are well known for their antioxidant activity. Recent research suggests that they also have a diverse array of neuroprotective functions that could lead to better treatments for neurodegenerative diseases. We present an overview of the effects of various polyphenols in cell line and animal models of ALS/FTD. Furthermore, possible mechanisms behind actions of the most researched compounds (resveratrol, curcumin and green tea catechins) are discussed.

• Language: English
• Keywords: ALS, EGCG, FTD, catechin, curcumin, neurodegeneration, polyphenols, resveratrol
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Publication status: Published
• Publication version: Version of Record
• Year: 2021
• Number of pages: 15 str.
• Numbering: Vol. 10, iss. 8, art. 1328
• PID: 20.500.12556/RUL-135952
• UDC: 577:616.8
• ISSN on article: 2076-3921
• DOI: 10.3390/antiox10081328
• COBISS.SI-ID: 75095555
• Publication date in RUL: 04.04.2022

Record is a part of a journal

• Title: Antioxidants
• Shortened title: Antioxidants
• Publisher: MDPI
• ISSN: 2076-3921
• COBISS.SI-ID: 522976025

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 23.08.2021

Secondary language

• Language: Slovenian
• Keywords: ALS, EGCG, FTD, katehin, kurkumin, nevrodegeneracija, polifenoli, resveratrol