Bleomycin concentration in patientsʹ plasma and tumors after electrochemotherapy : a study from InspECT Group
ID Grošelj, Aleš (Author), ID Bošnjak, Maša (Author), ID Kržan, Mojca (Author), ID Kosjek, Tina (Author), ID Bottyán, Krisztina (Author), ID Plešnik, Helena (Author), ID Jamšek, Črt (Author), ID Čemažar, Maja (Author), ID Kis, Erika (Author), ID Serša, Gregor (Author)

.pdfPDF - Presentation file, Download (665,51 KB)
URLURL - Source URL, Visit https://www.mdpi.com/1999-4923/13/9/1324 This link opens in a new window

The plasma concentration profile of bleomycin in the distribution phase of patients younger than 65 years is needed to determine the suitable time interval for efficient application of electric pulses during electrochemotherapy. Additionally, bleomycin concentrations in the treated tumors for effective tumor response are not known. In this study, the pharmacokinetic profile of bleomycin in the distribution phase in 12 patients younger than 65 years was determined. In 17 patients, the intratumoral bleomycin concentration was determined before the application of electric pulses. In younger patients, the pharmacokinetics of intravenously injected bleomycin demonstrated a faster plasma clearance rate than that in patients older than 65 years. This outcome might indicate that the lowering of the standard bleomycin dose of 15,000 IU/m$^2$ with intravenous bleomycin injection for electrochemotherapy is not recommended in younger patients. Based on the plasma concentration data gathered, a time interval for electrochemotherapy of 5–15 min after bleomycin injection was determined. The median bleomycin concentration in tumors 8 min after bleomycin injection, at the time of electroporation, was 170 ng/g. Based on collected data, the reduction of the bleomycin dose is not recommended in younger patients; however, a shortened time interval for application of electric pulses in electrochemotherapy to 5–15 min after intravenous bleomycin injection should be considered.

Keywords:electrochemotherapy, electroporation, bleomycin, pharmacokinetics, blood samples, tumor samples, drug delivery
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:MF - Faculty of Medicine
FFA - Faculty of Pharmacy
ZF - Faculty of Health Sciences
Publication status:Published
Publication version:Version of Record
Number of pages:12 str.
Numbering:Vol. 13, iss. 9, art. 1324
PID:20.500.12556/RUL-135949 This link opens in a new window
ISSN on article:1999-4923
DOI:10.3390/pharmaceutics13091324 This link opens in a new window
COBISS.SI-ID:74740739 This link opens in a new window
Publication date in RUL:04.04.2022
Copy citation
Share:Bookmark and Share

Record is a part of a journal

Shortened title:Pharmaceutics
COBISS.SI-ID:517949977 This link opens in a new window


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:01.09.2021

Secondary language

Keywords:elektrokemoterapija, elektroporacija, bleomycin


Funder:ARRS - Slovenian Research Agency
Project number:P3-0003
Name:Razvoj in ovrednotenje novih terapij za zdravljenje malignih tumorjev

Funder:ARRS - Slovenian Research Agency
Project number:P1-0143
Name:Kroženje snovi v okolju, snovna bilanca in modeliranje okoljskih procesov ter ocena tveganja

Funder:ARRS - Slovenian Research Agency
Project number:P3-0067
Name:Farmakologija in farmakogenomika

Funder:ARRS - Slovenian Research Agency
Project number:P3-0307
Name:Rak glave in vratu - analiza bioloških značilnosti in poskus izboljšanja zdravljenja

Funder:ARRS - Slovenian Research Agency
Project number:J3-9269
Name:Klinično farmakološki pristop k optimizaciji terapevtske koncentracije bleomicina za zdravljenje z elektrokemoterapijo

Similar documents

Similar works from RUL:
Similar works from other Slovenian collections: