Metronomic chemotherapy for palliative treatment of malignant oral tumors in dogs
ID Milevoj, Nina (Author), ID Nemec, Ana (Author), ID Tozon, Nataša (Author)

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The aim of this study was to evaluate the efficacy of metronomic chemotherapy in the palliative treatment of various malignant oral tumors in dogs. Our focus was to determine the effect of treatment on local disease control and to assess the tolerability and safety of the treatment in dogs with various oral malignancies. Metronomic chemotherapy with cyclophosphamide was used to treat 12 dogs and was combined with non-steroidal anti-inflammatory drugs in 6/12 (50%) of dogs. A clinical benefit was observed in 6/12 (50%) patients 1 month and in 4/12 (33%) 3 months after treatment initiation. The median survival time of the dogs was 155 days (range 21–529 days). At the end of the observation period, the disease had progressed in 10/12 (83.3%) of the patients. Sterile hemorrhagic cystitis was the most commonly reported side effect of treatment, occurring in 4/12 (33.3%) dogs. The results of our study suggest that metronomic chemotherapy with cyclophosphamide can be, in a subset of dogs, beneficial in the palliation of malignant oral tumors.

Keywords:metronomic chemotherapy, cyclophosphamide, malignant oral tumors, dogs, palliative treatment, drug therapy, neoplasms, palliative care
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:VF - Veterinary Faculty
Publication status:Published
Publication version:Version of Record
Number of pages:8 str.
Numbering:Vol. 9, art. 856399
PID:20.500.12556/RUL-135903 This link opens in a new window
ISSN on article:2297-1769
DOI:10.3389/fvets.2022.856399 This link opens in a new window
COBISS.SI-ID:102895107 This link opens in a new window
Publication date in RUL:31.03.2022
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Record is a part of a journal

Title:Frontiers in veterinary science
Shortened title:Front. vet. sci.
Publisher:Frontiers Media S.A.
COBISS.SI-ID:3969402 This link opens in a new window


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.


Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:P4-0053
Name:Endokrini, imunski in encimski odzivi pri zdravih in bolnih živalih

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:J4-2546
Name:Spremljanje kliničnega in imunskega odgovora za izboljšanje zdravljenja spontanih perifernih tumorjev psov s kombinacijo elektrokemoterapije in genskega elektroprenosa IL-12

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