The master's thesis addresses challenges of pharmaceutical solid forms of medicines crushing and breaking throughout the entire production process. Even the slightest deformation that can occur due to gravitational descents and are unavoidable in vertical production, lead to the ejection of the product. The tablets must have sufficient mechanical properties to prevent damage during the manufacturing process itself. At the same time, they must be weak enough for the end user to break them into equal parts according to the instructions for use, or for the tablet to decompose and release the active pharmaceutical ingredient in the body within a certain time frame. The thesis presents the entire production, the most common defects as well as quality control of pharmaceutical tablets. For the friability analysis, we used a simple system to perform gravitational descents from different heights. The results were compared with numerical simulations of performing a pharmaceutical strength test as well as gravity descents. We compared the deformations through different product shapes. We found that the challenge of friability needs to be addressed holistically and not just in terms of pharmaceutical tablet shapes.
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