Tie-2, G-CSF, and leptin as promising diagnostic biomarkers for endometrial cancer : a pilot study
ID Roškar, Luka (Author), ID Klančič, Teja (Author), ID Knific, Tamara (Author), ID Lanišnik-Rižner, Tea (Author), ID Smrkolj, Špela (Author)

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Preoperative determination of the extent of endometrial cancer (EC) would avoid the complications associated with radical surgery. Screening of patients' plasma biomarkers might enable a more precise diagnosis of EC and a tailored treatment approach. This prospective case-control monocentric pilot study included 76 postmenopausal women (38 endometrioid EC patients and 38 control patients with benign gynecological conditions), and 37 angiogenic factors (AFs) were investigated as potential biomarkers for EC. AF concentrations in preoperative plasma samples were measured using Luminex xMAP$^{TM}$ multiplexing technology. The plasma levels of sTie-2 and G-CSF were significantly lower in EC compared to control patients, whereas the plasma levels of leptin were significantly higher in EC patients. Neuropilin-1 plasma levels were significantly higher in patients with type 2 EC (grade 3) compared to patients with lower grade cancer or controls. Follistatin levels were significantly higher in patients with lymphovascular invasion, and IL-8 plasma levels were significantly higher in patients with metastases. If validated, the plasma concentrations of the indicated AFs could represent an important additional diagnostic tool for the early detection and characterization of EC. This could guide the decision-making on the extent of surgery. Further studies with larger patient numbers are currently ongoing.

Keywords:endometrial cancer, angiogenesis, biomarkers, angiogenic factors, Tie-2, G-CSF, leptin
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:MF - Faculty of Medicine
Publication status:Published
Publication version:Version of Record
Number of pages:11 str.
Numbering:Vol. 10, iss. 4, art. 765
PID:20.500.12556/RUL-134844 This link opens in a new window
ISSN on article:2077-0383
DOI:10.3390/jcm10040765 This link opens in a new window
COBISS.SI-ID:51545347 This link opens in a new window
Publication date in RUL:04.02.2022
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Record is a part of a journal

Title:Journal of clinical medicine
Shortened title:J. clin. med.
COBISS.SI-ID:5405759 This link opens in a new window


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:15.02.2021

Secondary language

Keywords:rak endometrija, angiogeneza, biomarkerji


Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:J3-8212
Name:Vloga intrakrinega delovanja estrogenov pri hormonsko odvisnih boleznih – pomen za zdravljenje

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:J3-2535
Name:Vloga androgenov pri hormonsko odvisnih boleznih: pomen za diagnostiko in zdravljenje

Funder:Drugi - Drug financer ali več financerjev
Funding programme:University Medical Centre Ljubljana
Project number:TP20190155

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