Insights into cell surface expression, supramolecular organization, and functions of aquaporin 4 isoforms in astrocytes
ID Jorgačevski, Jernej (Author), ID Zorec, Robert (Author), ID Potokar, Maja (Author)

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Aquaporin 4 (AQP4) is the most abundant water channel in the central nervous system (CNS). Its expression is confined to non-neuronal glial cells, predominantly to astrocytes that represent a heterogeneous glial cell type in the CNS. The membrane of astrocyte processes, which align brain capillaries and pia, is particularly rich in AQP4. Several isoforms of AQP4 have been described; however, only some (AQP4a (M1), AQP4 c (M23), AQP4e, and AQP4ex) have been identified in the plasma membrane assemblies of astrocytes termed orthogonal arrays of particles (OAPs). Intracellular splicing isoforms (AQP4b, AQP4d, AQP4f, AQP4-∆4) have been documented, and most of them are postulated to have a role in the cell surface distribution of the plasma membrane isoforms and in the formation of OAPs in murine and human astrocytes. Although OAPs have been proposed to play various roles in the functioning of astrocytes and CNS tissue as a whole, many of these still need to be described. OAPs are studied primarily from the perspective of understanding water permeability regulation through the plasma membrane and of their involvement in cell adhesion and in the dynamics of astrocytic processes. This review describes the cellular distribution of various AQP4 isoforms and their implications in OAP assembly, which is regulated by several intracellular and extracellular proteins.

Keywords:aquaporin 4 (AQP4), astrocyte, brain edema, glia, orthogonal arrays of particles (OAP), cell migration, extracellular matrix, hormones
Work type:Article
Typology:1.02 - Review Article
Organization:MF - Faculty of Medicine
Publication status:Published
Publication version:Version of Record
Number of pages:19 str.
Numbering:Vol. 9, iss. 12, art. 2622
PID:20.500.12556/RUL-134806 This link opens in a new window
ISSN on article:2073-4409
DOI:10.3390/cells9122622 This link opens in a new window
COBISS.SI-ID:41327875 This link opens in a new window
Publication date in RUL:02.02.2022
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Shortened title:Cells
COBISS.SI-ID:519958809 This link opens in a new window


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:07.12.2020

Secondary language

Keywords:akvaporin 4 (AQP4), astrocit, edem možganov


Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:P3-0310
Name:Celična fiziologija

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:J3-9266
Name:Uravnavanje fuzijske pore in motnje skladiščenja v lizosomih

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