High-sensitivity C-reactive protein and carotid intima media thickness as markers of subclinical inflammation and atherosclerosis in pediatric patients with hypercholesterolemia
ID Blinc, Lana (Author), ID Mlinarič, Matej (Author), ID Battelino, Tadej (Author), ID Grošelj, Urh (Author)

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Hypercholesterolemia is a major cause of atherosclerosis development and premature cardiovascular disease (CVD). It leads to inflammation, which further accelerates atherosclerosis progression. Familial hypercholesterolemia (FH) is an autosomal dominant disorder characterized by elevated serum LDL-c from birth, due to a disease-causing variant in one of the causative genes (LDLR, APOB, PCSK9). In polygenic hypercholesterolemia (PH), the disease-causing genetic variant is absent; it is likely the cumulative result of multiple single nucleotide polymorphisms in LDL metabolism-related genes and other factors, such as lifestyle and environment. In high risk groups, such as patients with FH, an effective primary prevention of CVD must begin in childhood. High-sensitivity C-reactive protein (hsCRP) and carotid intima media thickness (cIMT) are two potential minimally invasive correlates of inflammation and subclinical atherosclerosis progression. hsCRP and cIMT have been shown to be significantly increased in patients with FH and PH relative to healthy controls, with some studies yielding conflicting results. In this review, we aim to summarize current knowledge and recent findings regarding the applicability of hsCRP and cIMT as markers of low-grade inflammation and subclinical atherosclerosis, focusing especially on children and adolescents with hypercholesterolemia.

Keywords:familial hypercholesterolemia, polygenic hypercholesterolemia, inflammation, atherosclerosis, carotid intima media thickness, cIMT, C-reactive protein, hsCRP
Work type:Article
Typology:1.02 - Review Article
Organization:MF - Faculty of Medicine
Publication status:Published
Publication version:Version of Record
Number of pages:14 str.
Numbering:Vol. 25, iss. 21, art. 5118
PID:20.500.12556/RUL-134722 This link opens in a new window
ISSN on article:1420-3049
DOI:10.3390/molecules25215118 This link opens in a new window
COBISS.SI-ID:37628419 This link opens in a new window
Publication date in RUL:27.01.2022
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Shortened title:Molecules
COBISS.SI-ID:18462981 This link opens in a new window


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:04.11.2020


Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:J3-2356
Name:Izražanje in funkcionalna analiza nekodirajočih RNA pri parkinsonovi bolezni

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:P3-0343
Name:Etiologija, zgodnje odkrivanje in zdravljenje bolezni pri otrocih in mladostnikih

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