Copper(II) complexes with mixed heterocycle ligands as promising antibacterial and antitumor species

Rostas, Arpad Mihai (author), Badea, Mihaela (author), Ruţǎ, Lavinia L. (author), Farcaşanu, Ileana C. (author), Maxim, Cǎtǎlin (author), Chifiriuc, Mariana Carmen (author), Popa, Marcela (author), Luca, Mirela (author), Čelan Korošin, Nataša (author), Cerc Korošec, Romana (author), Bacalum, Mihaela (author), Raileanu, Mina (author), Olar, Rodica (author)

Complexes with mixed ligands [Cu(N-N)$_2$(pmtp)](ClO$_4$)$_2$ ((1) N-N: 2,2′-bipyridine; (2) L: 1,10-phenanthroline and pmpt: 5-phenyl-7-methyl-1,2,4-triazolo[1,5-a]pyrimidine) were synthesized and structurally and biologically characterized. Compound (1) crystallizes into space group Pa and (2) in P-1. Both complexes display an intermediate stereochemistry between the two five-coordinated ones. The biological tests indicated that the two compounds exhibited superoxide scavenging capacity, intercalative DNA properties, and metallonuclease activity. Tests on various cell systems indicated that the two complexes neither interfere with the proliferation of Saccharomyces cerevisiae or BJ healthy skin cells, nor cause hemolysis in the active concentration range. Nevertheless, the compounds showed antibacterial potential, with complex (2) being significantly more active than complex (1) against all tested bacterial strains, both in planktonic and biofilm growth state. Both complexes exhibited a very good activity against B16 melanoma cells, with a higher specificity being displayed by compound (1). Taken together, the results indicate that complexes (1) and (2) have specific biological relevance, with potential for the development of antitumor or antimicrobial drugs.

• Language: English
• Keywords: copper(II) complex, 1, 2, 4-triazolo[1, 5-a]pyrimidine, cytotoxicity, biofilm, metallonuclease activity, DNA intercalation
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Publication status: Published
• Publication version: Version of Record
• Year: 2020
• Number of pages: 22 str.
• Numbering: Vol. 25, iss. 17, art. 3777
• PID: 20.500.12556/RUL-134318
• UDC: 546.56:547.853
• ISSN on article: 1420-3049
• DOI: 10.3390/molecules25173777
• COBISS.SI-ID: 26455043
• Publication date in RUL: 05.01.2022

Record is a part of a journal

• Title: Molecules
• Shortened title: Molecules
• Publisher: MDPI
• ISSN: 1420-3049
• COBISS.SI-ID: 18462981

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 01.09.2020

Secondary language

• Language: Slovenian
• Keywords: baker, bakrovi kompleksi, 1, 2, 4-triazolo[1, 5-a]pirimidin, citotoksičnost

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P1-0134
• Name: Kemija za trajnostni razvoj