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The correlation between extracellular heat shock protein 70 and lipid metabolism in a ruminant model
ID
Petrović, Miloš Ž.
(
Author
),
ID
Cincović, M. R.
(
Author
),
ID
Starič, Jože
(
Author
),
ID
Djoković, Radojica
(
Author
),
ID
Belić, B.
(
Author
),
ID
Radinović, Miodrag
(
Author
),
ID
Majkić, Mira
(
Author
),
ID
Ilić, Zoran Ž.
(
Author
)
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https://www.mdpi.com/2218-1989/12/1/19
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Abstract
Metabolic stress in early lactation cows is characterized by lipolysis, ketogenesis, insulin resistance and inflammation because of negative energy balance and increased use of lipids for energy needs. In this study the relationship between lipid metabolite, lipid-based insulin resistance, and hepatocyte functionality indexes and tumor necrosis factor alpha (TNF-α) with extracellular heat shock protein 70 (eHsp70) was investigated. The experiment included 50 cows and all parameters were measured in blood serum. In cows with a more pronounced negative energy balance, the following was determined: a higher concentration of eHsp70, TNF-α, non-esterified fatty acid (NEFA), beta-hydroxybutyrate (BHB), NEFA to insulin and NEFA to cholesterol ratio and lower concentration of cholesterol, very low-density lipoproteins (VLDL), low density lipoproteins (LDL) and liver functionality index (LFI). The eHsp70 correlated negatively with the values of cholesterol, VLDL, LDL, and triglycerides, while correlated positively with the level of NEFA and BHB. A higher concentration of eHsp70 suggests the development of fatty liver (due to a higher NEFA to cholesterol ratio and lower LFI) and insulin resistance (due to a lower revised quantitative insulin sensitivity check index RQUICKI-BHB and higher NEFA to insulin ratio). The eHsp70 correlated positively with TNF-α. Both TNF-α and eHsp70 correlated similarly to lipid metabolites. In cows with high eHsp70 and TNF-α values we found higher concentrations of NEFA, BHB, NEFA to insulin and NEFA to cholesterol ratio and a lower concentration of triglycerides and VLDL cholesterol compared to cows that had only high TNF-α values. Based on the positive correlation between eHsp70 and TNF-α, their similar relations, and the additional effect of eHsp70 (high TNF-α + eHsp70 values) on lipid metabolites we conclude that eHsp70 has pro-inflammatory effects implicating lipolysis, fatty liver, and fat tissue insulin resistance.
Language:
English
Keywords:
cow
,
early lactation
,
chaperons
,
lipolysis
,
ketogensis
,
insulin resistance
,
fatty liver
,
negative energy balance
,
cattle
,
lactation
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
VF - Veterinary Faculty
Publication status:
Published
Publication version:
Version of Record
Year:
2022
Number of pages:
14 str.
Numbering:
Vol. 12, iss. 1, art. 19
PID:
20.500.12556/RUL-134220
UDC:
636.09:542
ISSN on article:
2079-6382
DOI:
10.3390/metabo12010019
COBISS.SI-ID:
91366915
Publication date in RUL:
30.12.2021
Views:
1534
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169
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Record is a part of a journal
Title:
Metabolites
Shortened title:
Metabolites
Publisher:
MDPI
ISSN:
2218-1989
COBISS.SI-ID:
523274009
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:
01.01.2022
Projects
Funder:
Other - Other funder or multiple funders
Funding programme:
Ministry of Education, Science and Technological Development
Project number:
451-03-9/2021-14/200117
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