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Crystallized TiO2 nanosurfaces in biomedical applications
ID Benčina, Metka (Author), ID Iglič, Aleš (Author), ID Mozetič, Miran (Author), ID Junkar, Ita (Author)

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Abstract
Crystallization alters the characteristics of TiO2 nanosurfaces, which consequently influences their bio-performance. In various biomedical applications, the anatase or rutile crystal phase is preferred over amorphous TiO2. The most common crystallization technique is annealing in a conventional furnace. Methods such as hydrothermal or room temperature crystallization, as well as plasma electrolytic oxidation (PEO) and other plasma-induced crystallization techniques, present more feasible and rapid alternatives for crystal phase initiation or transition between anatase and rutile phases. With oxygen plasma treatment, it is possible to achieve an anatase or rutile crystal phase in a few seconds, depending on the plasma conditions. This review article aims to address different crystallization techniques on nanostructured TiO2 surfaces and the influence of crystal phase on biological response. The emphasis is given to electrochemically anodized nanotube arrays and their interaction with the biological environment. A short overview of the most commonly employed medical devices made of titanium and its alloys is presented and discussed.

Language:English
Keywords:titanium oxide, nanostructure, crystalline phase, biocompatibility, surface modification
Work type:Article
Typology:1.02 - Review Article
Organization:FE - Faculty of Electrical Engineering
MF - Faculty of Medicine
Publication status:Published
Publication version:Version of Record
Year:2020
Number of pages:23 str.
Numbering:Vol. 10, iss. 6, art. 1121
PID:20.500.12556/RUL-133651 This link opens in a new window
UDC:620.3
ISSN on article:2079-4991
DOI:10.3390/nano10061121 This link opens in a new window
COBISS.SI-ID:19160835 This link opens in a new window
Publication date in RUL:07.12.2021
Views:1720
Downloads:221
Metadata:XML DC-XML DC-RDF
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BENČINA, Metka, IGLIČ, Aleš, MOZETIČ, Miran and JUNKAR, Ita, 2020, Crystallized TiO$_2$ nanosurfaces in biomedical applications. Nanomaterials [online]. 2020. Vol. 10, no. 6,  1121. [Accessed 19 July 2025]. DOI 10.3390/nano10061121. Retrieved from: https://repozitorij.uni-lj.si/IzpisGradiva.php?lang=eng&id=133651
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Record is a part of a journal

Title:Nanomaterials
Shortened title:Nanomaterials
Publisher:MDPI AG
ISSN:2079-4991
COBISS.SI-ID:523286297 This link opens in a new window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:06.06.2020

Projects

Funder:ARRS - Slovenian Research Agency
Project number:L7-7566
Name:Napredne hemokompatibilne površine žilnih opornic

Funder:ARRS - Slovenian Research Agency
Project number:J3-9262
Name:Napredne tehnologije obdelave individualiziranih 3D tiskanih implantatov za preprečevanje bakterijskih okužb

Funder:ARRS - Slovenian Research Agency
Project number:J1-9162
Name:Neurotoksičnost ali neuroprotektivnost nanomaterialov: vpliv biokorone

Funder:ARRS - Slovenian Research Agency
Project number:P2-0232
Name:Funkcije in tehnologije kompleksnih sistemov

Funder:ARRS - Slovenian Research Agency
Project number:P3-0314
Name:Sistemske avtoimunske bolezni

Funder:Other - Other funder or multiple funders
Funding programme:Ministry of Education, Science and Sport (Slovenia)

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