Crystallized TiO$_2$ nanosurfaces in biomedical applications

Benčina, Metka (author), Iglič, Aleš (author), Mozetič, Miran (author), Junkar, Ita (author)

Crystallization alters the characteristics of TiO$_2$ nanosurfaces, which consequently influences their bio-performance. In various biomedical applications, the anatase or rutile crystal phase is preferred over amorphous TiO$_2$. The most common crystallization technique is annealing in a conventional furnace. Methods such as hydrothermal or room temperature crystallization, as well as plasma electrolytic oxidation (PEO) and other plasma-induced crystallization techniques, present more feasible and rapid alternatives for crystal phase initiation or transition between anatase and rutile phases. With oxygen plasma treatment, it is possible to achieve an anatase or rutile crystal phase in a few seconds, depending on the plasma conditions. This review article aims to address different crystallization techniques on nanostructured TiO$_2$ surfaces and the influence of crystal phase on biological response. The emphasis is given to electrochemically anodized nanotube arrays and their interaction with the biological environment. A short overview of the most commonly employed medical devices made of titanium and its alloys is presented and discussed.

• Language: English
• Keywords: titanium oxide, nanostructure, crystalline phase, biocompatibility, surface modification
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: FE - Faculty of Electrical Engineering; MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2020
• Number of pages: 23 str.
• Numbering: Vol. 10, iss. 6, art. 1121
• PID: 20.500.12556/RUL-133651
• UDC: 620.3
• ISSN on article: 2079-4991
• DOI: 10.3390/nano10061121
• COBISS.SI-ID: 19160835
• Publication date in RUL: 07.12.2021

BENČINA, Metka, IGLIČ, Aleš, MOZETIČ, Miran and JUNKAR, Ita, 2020, Crystallized TiO$_2$ nanosurfaces in biomedical applications. Nanomaterials [online]. 2020. Vol. 10, no. 6,  1121. [Accessed 19 July 2025]. DOI 10.3390/nano10061121. Retrieved from: https://repozitorij.uni-lj.si/IzpisGradiva.php?lang=eng&id=133651

Record is a part of a journal

• Title: Nanomaterials
• Shortened title: Nanomaterials
• Publisher: MDPI AG
• ISSN: 2079-4991
• COBISS.SI-ID: 523286297

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 06.06.2020