Cannabinoids and hormone receptor-positive breast cancer treatment
ID Dobovišek, Luka (Author), ID Krstanović, Fran (Author), ID Borštnar, Simona (Author), ID Debeljak, Nataša (Author)

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Breast cancer (BC) is the most common cancer in women worldwide. Approximately 70–80% of BCs express estrogen receptors (ER), which predict the response to endocrine therapy (ET), and are therefore hormone receptor-positive (HR+). Endogenous cannabinoids together with cannabinoid receptor 1 and 2 (CB1, CB2) constitute the basis of the endocannabinoid system. Interactions of cannabinoids with hypothalamic–pituitary–gonadal axis hormones are well documented, and two studies found a positive correlation between peak plasma endogenous cannabinoid anandamide with peak plasma 17β-estradiol, luteinizing hormone and folliclestimulating hormone levels at ovulation in healthy premenopausal women. Do cannabinoids have an effect on HR+ BC? In this paper we review known and possible interactions between cannabinoids and specific HR+ BC treatments. In preclinical studies, CB1 and CB2 agonists (i.e., anandamide, THC) have been shown to inhibit the proliferation of ER positive BC cell lines. There is less evidence for antitumor cannabinoid action in HR+ BC in animal models and there are no clinical trials exploring the effects of cannabinoids on HR+ BC treatment outcomes. Two studies have shown that tamoxifen and several other selective estrogen receptor modulators (SERM) can act as inverse agonists on CB1 and CB2, an interaction with possible clinical consequences. In addition, cannabinoid action could interact with other commonly used endocrine and targeted therapies used in the treatment of HR+ BC.

Keywords:hormone receptor, breast cancer, cannabinoids, treatment, CBD, THC, estrogen, cannabinoid receptor
Work type:Article
Typology:1.02 - Review Article
Organization:MF - Faculty of Medicine
Publication status:Published
Publication version:Version of Record
Number of pages:12 str.
Numbering:Vol. 12, iss. 3, art. 525
PID:20.500.12556/RUL-133624 This link opens in a new window
ISSN on article:2072-6694
DOI:10.3390/cancers12030525 This link opens in a new window
COBISS.SI-ID:34716889 This link opens in a new window
Publication date in RUL:06.12.2021
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Record is a part of a journal

Shortened title:Cancers
COBISS.SI-ID:517914137 This link opens in a new window


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:01.03.2020

Secondary language

Keywords:hormonski receptor, rak dojke, kanabinoidi


Funder:ARRS - Slovenian Research Agency
Project number:P1-0390
Name:Funkcijska genomika in biotehnologija za zdravje

Funder:ARRS - Slovenian Research Agency
Project number:P3-0321
Name:Napovedni dejavniki poteka bolezni in odgovora na zdravljenje pri različnih vrstah raka

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