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Electronic emulator of biological tissue as an electrical load during electroporation
ID
Pirc, Eva
(
Author
),
ID
Balosetti, Bertrand
(
Author
),
ID
Miklavčič, Damijan
(
Author
),
ID
Reberšek, Matej
(
Author
)
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MD5: 9A78FD59A453269FD53C429310C80309
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https://www.mdpi.com/2076-3417/10/9/3103
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Abstract
Electroporation is an emerging technology, with great potential in many different medical and biotechnological applications, food engineering and biomass processing. Large variations of biological load characteristics, however, represent a great challenge in electroporator design, which results in different solutions. Because a clinical electroporator is a medical device, it must comply with medical device regulative and standards. However, none of the existing standards directly address the operation or electroporator’s performance requirements. In order to evaluate clinical, laboratory and prototype electroporation devices during the development process, or to evaluate their final performance considering at least from the perspective of output pulse parameters, we present a case study on the design of an electronic emulator of biological tissue as an electrical load during electroporation. The proposed electronic load emulator is a proof of concept, which enables constant and sustainable testing and unbiased comparison of different electroporators’ operations. We developed an analog electrical circuit that has equivalent impedance to the beef liver tissue in combination with needle electrodes, during high voltage pulse delivery and/or electroporation. Current and voltage measurements during electroporation of beef liver tissue ex vivo, were analyzed and parametrized to define the analog circuit equation. An equivalent circuit was simulated, built and validated. The proposed concept of an electronic load emulator can be used for “classical” electroporator (i.e., not nanosecond) performance evaluation and comparison of their operation. Additionally, it facilitates standard implementation regarding the testing protocol and enables quality assurance.
Language:
English
Keywords:
electroporation
,
tissue conductivity change
,
standard nonlinear load
,
biological load
,
electroporation emulator
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
FE - Faculty of Electrical Engineering
Publication status:
Published
Publication version:
Version of Record
Year:
2020
Number of pages:
15 str.
Numbering:
Vol. 10, iss. 9, art. 3103
PID:
20.500.12556/RUL-133368
UDC:
602.621
ISSN on article:
2076-3417
DOI:
10.3390/app10093103
COBISS.SI-ID:
13261059
Publication date in RUL:
24.11.2021
Views:
753
Downloads:
147
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Record is a part of a journal
Title:
Applied sciences
Shortened title:
Appl. sci.
Publisher:
MDPI
ISSN:
2076-3417
COBISS.SI-ID:
522979353
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:
01.05.2020
Secondary language
Language:
Slovenian
Keywords:
elektroporacija
,
sprememba prevodnosti tkiva
,
standardno nelinearno breme
,
biološko breme
,
emulator elektroporacije
Projects
Funder:
ARRS - Slovenian Research Agency
Project number:
I0-0022
Name:
Mreža raziskovalnih infrastrukturnih centrov Univerze v Ljubljani (MRIC UL)
Funder:
ARRS - Slovenian Research Agency
Project number:
P2-0249
Name:
Elektroporacija v biologiji, biotehnologiji in medicini
Funder:
ARRS - Slovenian Research Agency
Funding programme:
Junior Researchers
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