Characterization of biomarker levels in Crimean-Congo hemorrhagic fever and hantavirus fever with renal syndrome

Korva, Miša (author), Resman Rus, Katarina (author), Marušić, Miša (author), Saksida, Ana (author), Knap, Nataša (author), Jelovšek, Mateja (author), Strašek, Katja (author), Jakupi, Xhevat (author), Humolli, Isme (author), Dedushaj, Jusuf (author), Petrovec, Miroslav (author), Avšič-Županc, Tatjana (author)

Hemorrhagic fever with renal syndrome (HFRS) and Crimean-Congo hemorrhagic fever (CCHF) are important viral hemorrhagic fevers (VHF), especially in the Balkan region. Infections with Dobrava or Puumala orthohantavirus and Crimean-Congo hemorrhagic fever orthonairovirus can vary from a mild, nonspecific febrile illness, to a severe disease with a fatal outcome. The pathogenesis of both diseases is poorly understood, but it has been suggested that a host's immune mechanism might influence the pathogenesis of the diseases and survival. The aim of our study is to characterize cytokine response in patients with VHF in association with the disease progression and viral load. Forty soluble mediators of the immune response, coagulation, and endothelial dysfunction were measured in acute serum samples in 100 HFRS patients and 70 CCHF patients. HFRS and CCHF patients had significantly increased levels of IL-6, IL-12p70, IP-10, INF-γ, TNF-α, GM-CSF, MCP-3, and MIP-1b in comparison to the control group. Interestingly, HFRS patients had higher concentrations of serum MIP-1α, MIP-1β, which promote activation of macrophages and NK cells. HFRS patients had increased concentrations of IFN-γ and TNF-α, while CCHF patients had significantly higher concentrations of IFN-α and IL-8. In both, CCHF and HFRS patients' viral load significantly correlated with IP-10. Patients with fatal outcome had significantly elevated concentrations of IL-6, IFN-α2 and MIP-1α, while GRO-α, chemokine related to activation of neutrophils and basophils, was downregulated. Our study provided a comprehensive characterization of biomarkers released in the acute stages of CCHF and HFRS.

• Language: English
• Keywords: Crimean-Congo hemorrhagic fever, hantavirus fever, biomarkers, VHF, CCHF, HFRS, cytokines
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2019
• Number of pages: 19 str.
• Numbering: Vol. 11, iss. 8, art. 686
• PID: 20.500.12556/RUL-132852
• UDC: 616.9
• ISSN on article: 1999-4915
• DOI: 10.3390/v11080686
• COBISS.SI-ID: 34443481
• Publication date in RUL: 05.11.2021

Record is a part of a journal

• Title: Viruses
• Shortened title: Viruses
• Publisher: MDPI
• ISSN: 1999-4915
• COBISS.SI-ID: 517597977

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 01.08.2019

Secondary language

• Language: Slovenian
• Keywords: krimsko-kongoška hemoragična mrzlica, hantavirusna mrzlica, biomarkerji

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P3-0083
• Name: Odnosi parazitskega obstajanja

• Funder: EC - European Commission
• Funding programme: H2020
• Project number: 653316
• Name: European Virus Archive goes global
• Acronym: EVAg