Uric acid and plant-based nutrition

Jakše, Boštjan (author), Jakše, Barbara (author), Pajek, Maja (author), Pajek, Jernej (author)

Plant-based diets (PBDs) are associated with decreased risk of morbidity and mortality associated with important noncommunicable chronic diseases. Similar to animal-based food sources (e.g., meat, fish, and animal visceral organs), some plant-based food sources (e.g., certain soy legume products, sea vegetables, and brassica vegetables) also contain a high purine load. Suboptimally designed PBDs might consequently be associated with increased uric acid levels and gout development. Here, we review the available data on this topic, with a great majority of studies showing reduced risk of hyperuricemia and gout with vegetarian (especially lacto-vegetarian) PBDs. Additionally, type of ingested purines, fiber, vitamin C, and certain lifestyle factors work in concordance to reduce uric acid generation in PBDs. Recent limited data show that even with an exclusive PBD, uric acid concentrations remain in the normal range in short- and long-term dieters. The reasonable consumption of plant foods with a higher purine content as a part of PBDs may therefore be safely tolerated in normouricemic individuals, but additional data is needed in hyperuricemic individuals, especially those with chronic kidney disease.

• Language: English
• Keywords: uric acid, plant-based diets, chronic diseases, purine, hyperuricemia, gout
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: BF - Biotechnical Faculty; FŠ - Faculty of Sport
• Publication status: Published
• Publication version: Version of Record
• Year: 2019
• Number of pages: 15 str.
• Numbering: Vol. 11, iss. 8, art. 1736
• PID: 20.500.12556/RUL-132827
• UDC: 616.6
• ISSN on article: 2072-6643
• DOI: 10.3390/nu11081736
• COBISS.SI-ID: 6381484
• Publication date in RUL: 04.11.2021

Record is a part of a journal

• Title: Nutrients
• Shortened title: Nutrients
• Publisher: MDPI
• ISSN: 2072-6643
• COBISS.SI-ID: 2948140

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 01.08.2019

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P3-0323
• Name: Ledvične bolezni in nadomestna zdravljenja