Randomized, double-blinded, controlled trial of the effects of coenzyme Q10 supplementation on plasma coenzyme Q10 concentration in dogs with myxomatous mitral valve disease

Druzhaeva, Natalia (author), Domanjko-Petrič, Aleksandra (author), Tavčar-Kalcher, Gabrijela (author), Babič, Janja (author), Nemec Svete, Alenka (author)

OBJECTIVE To determine the dose of coenzyme Q10 (CoQ10) needed to achieve at least a 3-fold increase in plasma CoQ10 concentration in dogs with myxomatous mitral valve disease (MMVD) and congestive heart failure (CHF). ANIMALS 18 dogs with CHF due to MMVD and 12 healthy dogs. PROCEDURES In a randomized, double-blinded, controlled trial, dogs with MMVD were given 50 or 100 mg of water-soluble CoQ10 (ubiquinone; total daily dose, 100 mg [n = 5] or 200 mg [6]) or a placebo (7), PO, twice a day for 2 weeks in addition to regular cardiac treatment. Plasma CoQ10 concentration was measured in dogs with MMVD before (baseline) and at various time points after supplementation began and in healthy dogs once. Concentrations were compared among and within groups. RESULTS No significant difference in median baseline plasma CoQ10 concentration was detected between healthy dogs and dogs with MMVD. Fold increases in plasma CoQ10 concentrations ranged from 1.7 to 4.7 and 3.2 to 6.8 for in- dividual dogs in the 100-mg and 200-mg groups, respectively. The change in plasma CoQ10 concentration after supplementation began was significantly higher than in the placebo group at 4 hours and 1 and 2 weeks for dogs in the 200-mg group and at 1 and 2 weeks for dogs in the 100-mg group. CONCLUSIONS AND CLINICAL RELEVANCE A daily CoQ10 dose of 200 mg was sufficient to achieve at least a 3-fold increase in plasma CoQ10 concentration and may be used in CoQ10 supple- mentation studies involving dogs with CHF due to MMVD.

• Language: English
• Keywords: congestive heart failure, coenzyme Q10, myxomatous mitral valve disease, dogs
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: VF - Veterinary Faculty
• Publication status: Published
• Publication version: Author Accepted Manuscript
• Article acceptance date: 17.08.2020
• Year: 2021
• Number of pages: Str. 280-285
• Numbering: Vol. 82, no. 4
• PID: 20.500.12556/RUL-132360
• UDC: 636.09:616
• ISSN on article: 0002-9645
• DOI: 10.2460/ajvr.82.4.280
• COBISS.SI-ID: 57671939
• Publication date in RUL: 22.10.2021

Record is a part of a journal

• Title: American journal of veterinary research
• Shortened title: Am. j. vet. res.
• Publisher: American Veterinary Medical Association.
• ISSN: 0002-9645
• COBISS.SI-ID: 5084423

Licences

• License: CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
• Link: http://creativecommons.org/licenses/by-nc-nd/4.0/
• Description: The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
• Licensing start date: 15.04.2021

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P4-0053
• Name: Endokrini, imunski in encimski odzivi pri zdravih in bolnih živalih