Microfluidic technology for clinical applications of exosomes

Iliescu, Florina Silvia (author), Vrtačnik, Danilo (author), Neuzil, Pavel (author), Iliescu, Ciprian (author)

Exosomes, a type of nanovesicle, are distinct cellular entities specifically capable of carrying various cargos between cells. It has been hypothesized that exosomes, as an enriched source of biomolecules, may serve as biomarkers for various diseases. This review introduces general aspects of exosomes, presents the challenges in exosome research, discusses the potential of exosomes as biomarkers, and describes the contribution of microfluidic technology to enable their isolation and analysis for diagnostic and disease monitoring. Additionally, clinical applications of exosomes for diagnostic purposes are also summarized.

• Language: English
• Keywords: microfluidics, exosomes, clinical applications, extracellular vesicles, cancer, inflammation
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: FE - Faculty of Electrical Engineering
• Publication status: Published
• Publication version: Version of Record
• Year: 2019
• Number of pages: 29 str.
• Numbering: Vol. 10, iss. 6, art. 392
• PID: 20.500.12556/RUL-132230
• UDC: 616-006:621.38
• ISSN on article: 2072-666X
• DOI: 10.3390/mi10060392
• COBISS.SI-ID: 12545876
• Publication date in RUL: 18.10.2021

Record is a part of a journal

• Title: Micromachines
• Shortened title: Micromachines
• Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
• ISSN: 2072-666X
• COBISS.SI-ID: 523276825

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 12.06.2019

Secondary language

• Language: Slovenian
• Keywords: mikrofluidika, eksosomi, klinične aplikacije, zunajcelični vezikli, rak, vnetje

Projects

• Funder: Other - Other funder or multiple funders
• Funding programme: P.R. China
• Project number: W099109
• Name: Foreign Experts Program

• Funder: Other - Other funder or multiple funders
• Funding programme: Czech Republic
• Project number: GA16-11140S