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Stress-tolerant yeasts : opportunistic pathogenicity versus biocontrol potential
ID
Zajc, Janja
(
Author
),
ID
Gostinčar, Cene
(
Author
),
ID
Černoša, Anja
(
Author
),
ID
Gunde-Cimerman, Nina
(
Author
)
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https://www.mdpi.com/2073-4425/10/1/42
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Abstract
Stress-tolerant fungi that can thrive under various environmental extremes are highly desirable for their application to biological control, as an alternative to chemicals for pest management. However, in fungi, the mechanisms of stress tolerance might also have roles in mammal opportunism. We tested five species with high biocontrol potential in agriculture (Aureobasidium pullulans, Debayomyces hansenii, Meyerozyma guilliermondii, Metschnikowia fructicola, Rhodotorula mucilaginosa) and two species recognized as emerging opportunistic human pathogens (Exophiala dermatitidis, Aureobasidium melanogenum) for growth under oligotrophic conditions and at 37 °C, and for tolerance to oxidative stress, formation of biofilms, production of hydrolytic enzymes and siderophores, and use of hydrocarbons as sole carbon source. The results show large overlap between traits desirable for biocontrol and traits linked to opportunism (growth under oligotrophic conditions, production of siderophores, high oxidative stress tolerance, and specific enzyme activities). Based on existing knowledge and these data, we suggest that oligotrophism and thermotolerance together with siderophore production at 37 °C, urease activity, melanization, and biofilm production are the main traits that increase the potential for fungi to cause opportunistic infections in mammals. These traits should be carefully considered when assessing safety of potential biocontrol agents.
Language:
English
Keywords:
opportunistic pathogen
,
biocontrol agent
,
virulence
,
stress tolerance
,
secretome
,
CAZy
,
protease
,
thermotolerance
,
oligotrophism
,
melanin
,
siderophore
,
biofilm
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
BF - Biotechnical Faculty
Publication status:
Published
Publication version:
Version of Record
Year:
2019
Number of pages:
23 str.
Numbering:
Vol. 10, iss. 1, art. 42
PID:
20.500.12556/RUL-131969
UDC:
579
ISSN on article:
2073-4425
DOI:
10.3390/genes10010042
COBISS.SI-ID:
4966223
Publication date in RUL:
07.10.2021
Views:
637
Downloads:
159
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Record is a part of a journal
Title:
Genes
Shortened title:
Genes
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
ISSN:
2073-4425
COBISS.SI-ID:
523100185
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:
14.01.2019
Projects
Funder:
ARRS - Slovenian Research Agency
Project number:
Z7-7436
Name:
Na stres tolerantne kvasovke iz rodu Aureobasidium: uporaba v biološki kontroli nekaterih rastlinskih bolezni
Funder:
ARRS - Slovenian Research Agency
Project number:
P1-0170
Name:
Molekulski mehanizmi uravnavanja celičnih procesov v povezavi z nekaterimi boleznimi pri človeku
Funder:
ARRS - Slovenian Research Agency
Project number:
P1-0207
Name:
Toksini in biomembrane
Funder:
ARRS - Slovenian Research Agency
Project number:
I0-0021
Name:
Infrastrukturni center za raziskave molekulskih interakcij, Razvojno raziskovalni center za proučevanje rasti in razvoja kmetijskih rastlin, IC Mycosmo
Funder:
ARRS - Slovenian Research Agency
Project number:
I0-0022
Name:
Mreža raziskovalnih infrastrukturnih centrov Univerze v Ljubljani (MRIC UL)
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