Your browser does not allow JavaScript!
JavaScript is necessary for the proper functioning of this website. Please enable JavaScript or use a modern browser.
Open Science Slovenia
Open Science
DiKUL
slv
|
eng
Search
Browse
New in RUL
About RUL
In numbers
Help
Sign in
One-pot method for preparation of magnetic multi-core nanocarriers for drug delivery
ID
Dragar, Črt
(
Author
),
ID
Potrč, Tanja
(
Author
),
ID
Nemec, Sebastjan
(
Author
),
ID
Roškar, Robert
(
Author
),
ID
Pajk, Stane
(
Author
),
ID
Kocbek, Petra
(
Author
),
ID
Kralj, Slavko
(
Author
)
PDF - Presentation file,
Download
(2,10 MB)
MD5: 3EDEA034009A924FB23A8F1CBBD79599
URL - Source URL, Visit
https://www.mdpi.com/1996-1944/12/3/540
Image galllery
Abstract
The development of various magnetically-responsive nanostructures is of great importance in biomedicine. The controlled assembly of many small superparamagnetic nanocrystals into large multi-core clusters is needed for effective magnetic drug delivery. Here, we present a novel one-pot method for the preparation of multi-core clusters for drug delivery (i.e., magnetic nanocarriers). The method is based on hot homogenization of a hydrophobic phase containing a nonpolar surfactant into an aqueous phase, using ultrasonication. The solvent-free hydrophobic phase that contained tetradecan-1-ol, γ-Fe$_2$O$_3$ nanocrystals, orlistat, and surfactant was dispersed into a warm aqueous surfactant solution, with the formation of small droplets. Then, a pre-cooled aqueous phase was added for rapid cooling and the formation of solid magnetic nanocarriers. Two different nonpolar surfactants, polyethylene glycol dodecyl ether (B4) and our own N$^1$,N$^1$-dimethyl-N$^2$-(tricosan-12-yl)ethane-1,2-diamine (SP11), were investigated for the preparation of MC-B4 and MC-SP11 magnetic nanocarriers, respectively. The nanocarriers formed were of spherical shape, with mean hydrodynamic sizes <160 nm, good colloidal stability, and high drug loading (7.65 wt.%). The MC-B4 nanocarriers showed prolonged drug release, while no drug release was seen for the MC-SP11 nanocarriers over the same time frame. Thus, the selection of a nonpolar surfactant for preparation of magnetic nanocarriers is crucial to enable drug release from nanocarrier.
Language:
English
Keywords:
magnetic nanocrystals
,
magnetic drug delivery
,
nanocarriers
,
multi-core particles
,
magnetic nanoparticles
,
drug release
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
FFA - Faculty of Pharmacy
Publication status:
Published
Publication version:
Version of Record
Year:
2019
Number of pages:
14 str.
Numbering:
Vol. 12, iss. 3, art. 540
PID:
20.500.12556/RUL-131929
UDC:
620.3
ISSN on article:
1996-1944
DOI:
10.3390/ma12030540
COBISS.SI-ID:
32095527
Publication date in RUL:
06.10.2021
Views:
846
Downloads:
161
Metadata:
Cite this work
Plain text
BibTeX
EndNote XML
EndNote/Refer
RIS
ABNT
ACM Ref
AMA
APA
Chicago 17th Author-Date
Harvard
IEEE
ISO 690
MLA
Vancouver
:
Copy citation
Share:
Record is a part of a journal
Title:
Materials
Shortened title:
Materials
Publisher:
Molecular Diversity Preservation International
ISSN:
1996-1944
COBISS.SI-ID:
33588485
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:
12.02.2019
Projects
Funder:
ARRS - Slovenian Research Agency
Project number:
P2-0089
Name:
Sodobni magnetni in večnamenski materiali
Funder:
ARRS - Slovenian Research Agency
Project number:
J1-7302
Name:
Nanoteranostiki na osnovi magnetno odzivnih materialov
Funder:
ARRS - Slovenian Research Agency
Project number:
J3-7494
Name:
Tunelske membranske nanocevke za inovativno zdravljenje raka sečnega mehurja
Funder:
ARRS - Slovenian Research Agency
Project number:
P1-0189
Name:
Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih
Similar documents
Similar works from RUL:
Similar works from other Slovenian collections:
Back