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One-pot method for preparation of magnetic multi-core nanocarriers for drug delivery
ID Dragar, Črt (Author), ID Potrč, Tanja (Author), ID Nemec, Sebastjan (Author), ID Roškar, Robert (Author), ID Pajk, Stane (Author), ID Kocbek, Petra (Author), ID Kralj, Slavko (Author)

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Abstract
The development of various magnetically-responsive nanostructures is of great importance in biomedicine. The controlled assembly of many small superparamagnetic nanocrystals into large multi-core clusters is needed for effective magnetic drug delivery. Here, we present a novel one-pot method for the preparation of multi-core clusters for drug delivery (i.e., magnetic nanocarriers). The method is based on hot homogenization of a hydrophobic phase containing a nonpolar surfactant into an aqueous phase, using ultrasonication. The solvent-free hydrophobic phase that contained tetradecan-1-ol, γ-Fe$_2$O$_3$ nanocrystals, orlistat, and surfactant was dispersed into a warm aqueous surfactant solution, with the formation of small droplets. Then, a pre-cooled aqueous phase was added for rapid cooling and the formation of solid magnetic nanocarriers. Two different nonpolar surfactants, polyethylene glycol dodecyl ether (B4) and our own N$^1$,N$^1$-dimethyl-N$^2$-(tricosan-12-yl)ethane-1,2-diamine (SP11), were investigated for the preparation of MC-B4 and MC-SP11 magnetic nanocarriers, respectively. The nanocarriers formed were of spherical shape, with mean hydrodynamic sizes <160 nm, good colloidal stability, and high drug loading (7.65 wt.%). The MC-B4 nanocarriers showed prolonged drug release, while no drug release was seen for the MC-SP11 nanocarriers over the same time frame. Thus, the selection of a nonpolar surfactant for preparation of magnetic nanocarriers is crucial to enable drug release from nanocarrier.

Language:English
Keywords:magnetic nanocrystals, magnetic drug delivery, nanocarriers, multi-core particles, magnetic nanoparticles, drug release
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Publication status:Published
Publication version:Version of Record
Year:2019
Number of pages:14 str.
Numbering:Vol. 12, iss. 3, art. 540
PID:20.500.12556/RUL-131929 This link opens in a new window
UDC:620.3
ISSN on article:1996-1944
DOI:10.3390/ma12030540 This link opens in a new window
COBISS.SI-ID:32095527 This link opens in a new window
Publication date in RUL:06.10.2021
Views:763
Downloads:145
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Record is a part of a journal

Title:Materials
Shortened title:Materials
Publisher:Molecular Diversity Preservation International
ISSN:1996-1944
COBISS.SI-ID:33588485 This link opens in a new window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:12.02.2019

Projects

Funder:ARRS - Slovenian Research Agency
Project number:P2-0089
Name:Sodobni magnetni in večnamenski materiali

Funder:ARRS - Slovenian Research Agency
Project number:J1-7302
Name:Nanoteranostiki na osnovi magnetno odzivnih materialov

Funder:ARRS - Slovenian Research Agency
Project number:J3-7494
Name:Tunelske membranske nanocevke za inovativno zdravljenje raka sečnega mehurja

Funder:ARRS - Slovenian Research Agency
Project number:P1-0189
Name:Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih

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