Polymer-mediated delivery of siRNAs to hepatocellular carcinoma : variables affecting specificity and effectiveness

Farra, Rossella (author), Musiani, Francesco (author), Perrone, Francesca (author), Čemažar, Maja (author), Kamenšek, Urška (author), Tonon, Federica (author), Abrami, Michela (author), Ručigaj, Aleš (author), Grassi, Mario (author), Pozzato, Gabriele (author), Bonazza, Deborah (author), Zanconati, Fabrizio (author), Forte, Giancarlo (author), El Boustani, Maguie (author), Scarabel, Lucia (author), Garziera, Marica (author), Russo Spena, Concetta (author), De Stefano, Lucia (author), Salis, Barbara (author), Toffoli, Giuseppe (author), Rizzolio, Flavio (author), Grassi, Gabriele (author), Dapas, Barbara (author)

Despite the advances in anticancer therapies, their effectiveness for many human tumors is still far from being optimal. Significant improvements in treatment efficacy can come from the enhancement of drug specificity. This goal may be achieved by combining the use of therapeutic molecules with tumor specific effects and delivery carriers with tumor targeting ability. In this regard, nucleic acid-based drug (NABD) and particularly small interfering RNAs (siRNAs), are attractive molecules due to the possibility to be engineered to target specific tumor genes. On the other hand, polymeric-based delivery systems are emerging as versatile carriers to generate tumor-targeted delivery systems. Here we will focus on the most recent findings in the selection of siRNA/polymeric targeted delivery systems for hepatocellular carcinoma (HCC), a human tumor for which currently available therapeutic approaches are poorly effective. In addition, we will discuss the most attracting and, in our opinion, promising siRNA-polymer combinations for HCC in relation to the biological features of HCC tissue. Attention will be also put on the mathematical description of the mechanisms ruling siRNA-carrier delivery, this being an important aspect to improve effectiveness reducing the experimental work.

• Language: English
• Keywords: optimized drug delivery, anticancer drugs, HCC, siRNA
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Publication status: Published
• Publication version: Version of Record
• Year: 2018
• Number of pages: 24 str.
• Numbering: Vol. 23, iss. 4, art. 777
• PID: 20.500.12556/RUL-131823
• UDC: 602.6/.7
• ISSN on article: 1420-3049
• DOI: 10.3390/molecules23040777
• COBISS.SI-ID: 2895739
• Publication date in RUL: 04.10.2021

Record is a part of a journal

• Title: Molecules
• Shortened title: Molecules
• Publisher: MDPI
• ISSN: 1420-3049
• COBISS.SI-ID: 18462981

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 01.04.2018

Secondary language

• Language: Slovenian
• Keywords: izboljšana dostava učinkovin, onkološka zdravila, rak jeter, hepatocelularni rak