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Dvojno slepa randomizirana in s placebom nadzorovana raziskava kozmetičnih izdelkov s kanabidiolom
ID Kugonič, Neža (Author), ID Tavčar, Eva (Mentor) More about this mentor... This link opens in a new window

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Abstract
Dosedanje raziskave potrjujejo obstoj funkcionalnega endokanabinoidnega sistema v koži, ki med drugim vpliva na pravilno in uravnoteženo proliferacijo, diferenciacijo in toleranco kožnih celic ter regulacijo imunskega in vnetnega odziva. V zadnjem obdobju se zato izvaja vedno več raziskav topikalne uporabe kanabidiola, ki je eden izmed kanabinoidov, prisotnih v konoplji. Poleg pozitivnega vpliva kanabidiola na kožo, ugotavljajo tudi pozitivne učinke v ustni votlini, saj kanabidiol izkazuje obetavne baktericidne lastnosti proti aerobnim bakterijam v zobnih oblogah, ki so glavni vzrok za pojav različnih zobnih težav in bolezni. Izvedli smo dvojno slepo randomizirano in s placebom nadzorovano raziskavo kozmetičnih izdelkov s kanabidiolom. Preizkušali smo vlažilni in oljni serum za obraz, ustno vodo in peno za intimno nego. V raziskavi je sodelovalo dvajset prostovoljcev, ki so štirinajst dni preizkušali kozmetične izdelke s kanabidiolom in štirinajst dni placebo kozmetične izdelke. Namen raziskave je bil ugotoviti, kako uporaba kozmetičnih izdelkov s kanabidiolom, po mnenju prostovoljcev, vpliva na kožo, sluznico intimnih predelov in stanje v ustni votlini v primerjavi s placebom. Po preizkušanju vseh naštetih kozmetičnih izdelkov smo s pomočjo vprašalnikov pridobili in primerjali subjektivne ocene prostovoljcev ter ugotavljali učinkovitost vlažilnega in oljnega seruma za obraz z uporabo fotografij. Prostovoljci so v povprečju ocenili, da sta imela seruma za obraz s kanabidiolom v primerjavi s placebom večji vpliv na izboljšanje elastičnosti, vlažnosti in gladkosti kože na obrazu ter da sta izboljšala suhost kože, zmanjšala trenutno prisotnost rdečice in malo zmanjšala vidnost gub ter por na obrazu. Pri primerjavi ustnih vod so ocenili, da med njima ni razlik. Pri intimnih penah so v povprečju ocenili, da ima placebo večji pozitiven vpliv na pekoč občutek in občutek suhosti na intimnih predelih. Učinkovitost serumov za obraz smo preverjali tudi s pomočjo fotografij obrazov prostovoljcev, katere smo obdelali v aplikaciji Vichy SKINCONSULT AL®, ki ovrednoti številne parametre na koži obraza. Po statistični obdelavi smo sklenili, da aplikacija ni bila primerna za ugotavljanje učinkovitosti, saj je preveč občutljiva na svetlobo in kot fotografiranja obraza, v naši raziskavi pa ta parametra nista bila konstantna, saj fotografiranj nismo izvajali v ponovljivih razmerah. Poleg tega so ocenjevalci poskušali oceniti, katere fotografije so bile pridobljene po uporabi serumov s kanabidiolom, in tako ugotoviti, če se po uporabi kažejo vidni učinki na izgled kože obraza. Izkazalo se je, da ta način ocenjevanja zaradi kakovosti fotografij ni bil primeren za pridobitev relevantnih rezultatov.

Language:Slovenian
Keywords:kanabidiol, serum za obraz, intimna pena, ustna voda, kozmetični izdelki
Work type:Master's thesis/paper
Organization:FFA - Faculty of Pharmacy
Year:2021
PID:20.500.12556/RUL-131734 This link opens in a new window
Publication date in RUL:02.10.2021
Views:1794
Downloads:156
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Secondary language

Language:English
Title:Double-blind randomized placebo-controlled study of cannabidiol containing cosmetic products
Abstract:
Studies have confirmed that there is a functional endocannabinoid system in the skin which plays a role in healthy and balanced proliferation, differentiation, tolerance of skin cells, and in the regulation of immune and inflammatory response, among other functions. For this reason, there is more and more research into the topical use of cannabidiol, one of the cannabinoids in cannabis. Besides cannabidiol’s beneficial effects on the skin, positive effects have also been observed in the oral cavity due to its promising bactericidal properties against the aerobic bacteria in dental plaques, the main cause of various dental problems. We performed a double blind, randomised, placebo-controlled trial of cosmetic products that contain cannabidiol. A moisturising face serum, an oily face serum, a mouthwash, and an intimate foam were tested. The study included 20 volunteers, who were using cosmetic products with cannabidiol for 14 days and placebo products for 14 days. The purpose of the trial was to assess how cosmetic products with cannabidiol affect the skin, the intimal mucosa and the condition of the oral cavity in comparison with placebo, according to volunteer reports. After completed testing of all the products we used questionnaires to record and compare the subjective opinions of the volunteers. Furthermore, we evaluated the efficacy of the moisturising and oily face serums with photography. On average, the volunteers estimated that the two cannabidiol face serums outperformed placebo in the improvement of face skin elasticity, hydration and smoothness. The serums also improved skin dryness, decreased redness, and led to a small reduction of visible wrinkles and pores on the face. For the mouthwash, no difference with placebo was observed on average. For the intimate foam, however, the placebo led to a greater average reduction of burning and dryness sensations in the intimal mucosa, according to the volunteer reports. The efficacy of the face serums was also studied by processing the photos of the volunteers' faces with the Vichy SKINCONSULT AL® application, which takes into account a number of facial skin parameters. After statistical analysis, we realised that the application is not an appropriate tool for evaluating efficacy, since it is overly sensitive to the lighting and the camera angle. These two parameters were not constant in our trial, since the photo shoots were not conducted in a laboratory. Moreover, the photos were searched to try to identify those taken after the use of the cannabidiol serums, in order to see if any effects on the appearance of facial skin can be observed. We concluded that this method of evaluation, due to the quality of the photographs, was not suitable for obtaining relevant results.

Keywords:cannabidiol, face serum, intimate foam, mouthwash, cosmetic products

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