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The biological fate of silver nanoparticles from a methodological perspective
ID
Drobne, Damjana
(
Author
),
ID
Novak, Sara
(
Author
),
ID
Talaber, Iva
(
Author
),
ID
Lynch, Iseult
(
Author
),
ID
Jemec Kokalj, Anita
(
Author
)
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MD5: 89054580F0C697D0749F080FC83330E6
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http://www.mdpi.com/1996-1944/11/6/957
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Abstract
We analyzed the performance and throughput of currently available analytical techniques for quantifying body burden and cell internalization/distribution of silver nanoparticles (Ag NPs). Our review of Ag NP biological fate data shows that most of the evidence gathered for Ag NPs body burden actually points to total Ag and not only Ag NPs. On the other hand, Ag NPs were found inside the cells and tissues of some organisms, but comprehensive explanation of the mechanism(s) of NP entry and/or in situ formation is usually lacking. In many cases, the methods used to detect NPs inside the cells could not discriminate between ions and particles. There is currently no single technique that would discriminate between the metals species, and at the same time enable localization and quantification of NPs down to the cellular level. This paper serves as an orientation towards selection of the appropriate method for studying the fate of Ag NPs in line with their properties and the specific question to be addressed in the study. Guidance is given for method selection for quantification of NP uptake, biodistribution, precise tissue and cell localization, bioaccumulation, food chain transfer and modeling studies regarding the optimum combination of methods and key factors to consider.
Language:
English
Keywords:
silver nanoparticles review
,
body burden
,
biodistribution
,
internalization
,
bioaccumulation
,
microscopy
,
spectroscopy
,
throughput
,
performance
,
quantification
Work type:
Article
Typology:
1.02 - Review Article
Organization:
BF - Biotechnical Faculty
Publication status:
Published
Publication version:
Version of Record
Year:
2018
Number of pages:
12 str.
Numbering:
Vol. 11, iss. 6, art. 957
PID:
20.500.12556/RUL-131726
UDC:
620.3
ISSN on article:
1996-1944
DOI:
10.3390/ma11060957
COBISS.SI-ID:
4711247
Publication date in RUL:
01.10.2021
Views:
781
Downloads:
147
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Record is a part of a journal
Title:
Materials
Shortened title:
Materials
Publisher:
Molecular Diversity Preservation International
ISSN:
1996-1944
COBISS.SI-ID:
33588485
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:
05.06.2018
Projects
Funder:
EC - European Commission
Funding programme:
FP7
Project number:
310451
Name:
Engineered nanomaterial mechanisms of interactions with living systems and the environment: a universal framework for safe nanotechnology
Acronym:
NANOMILE
Funder:
EC - European Commission
Funding programme:
H2020
Project number:
646002
Name:
Nanomaterial FAte and Speciation in the Environment
Acronym:
NanoFASE
Funder:
ARRS - Slovenian Research Agency
Project number:
P1-0184
Name:
Integrativna zoologija in speleobiologija
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