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Astrocyte aquaporin dynamics in health and disease
ID Potokar, Maja (Author), ID Jorgačevski, Jernej (Author), ID Zorec, Robert (Author)

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Abstract
The family of aquaporins (AQPs), membrane water channels, consists of diverse types of proteins that are mainly permeable to water; some are also permeable to small solutes, such as glycerol and urea. They have been identified in a wide range of organisms, from microbes to vertebrates and plants, and are expressed in various tissues. Here, we focus on AQP types and their isoforms in astrocytes, a major glial cell type in the central nervous system (CNS). Astrocytes have anatomical contact with the microvasculature, pia, and neurons. Of the many roles that astrocytes have in the CNS, they are key in maintaining water homeostasis. The processes involved in this regulation have been investigated intensively, in particular regulation of the permeability and expression patterns of different AQP types in astrocytes. Three aquaporin types have been described in astrocytes: aquaporins AQP1 and AQP4 and aquaglyceroporin AQP9. The aim here is to review their isoforms, subcellular localization, permeability regulation, and expression patterns in the CNS. In the human CNS, AQP4 is expressed in normal physiological and pathological conditions, but astrocytic expression of AQP1 and AQP9 is mainly associated with a pathological state.

Language:English
Keywords:aquaporin (AQP), astrocyte, brain edema, glia, aquaporin isoforms, orthogonal arrays of particles (OAPs)
Work type:Article (dk_c)
Typology:1.02 - Review Article
Organization:MF - Faculty of Medicine
Year:2016
Publication status in journal:Published
Article version:Publisher's version of article
Number of pages:18 str.
Numbering:Vol. 17, iss. 7, art. 1121
UDC:616.8
ISSN on article:1422-0067
DOI:10.3390/ijms17071121 This link opens in a new window
COBISS.SI-ID:32739033 This link opens in a new window
Publication date in RUL:29.09.2021
Views:151
Downloads:52
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Record is a part of a journal

Title:International journal of molecular sciences
Shortened title:Int. j. mol. sci.
Publisher:MDPI
ISSN:1422-0067
COBISS.SI-ID:2779162 This link opens in a new window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:13.07.2016

Secondary language

Language:Slovenian
Keywords:akvaporin, astrocit, možganski edem

Document is financed by a project

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project number:P3-0310
Name:Celična fiziologija

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project number:J3-3632
Name:Molekularne lastnosti fuzijske pore

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project number:J3-4051
Name:Vloga monomernih GTPaz pri uravnavanju mobilnosti endosomov/lizosomov v astrocitih

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project number:J3-4146
Name:Mobilnost sekrecijskih mešičkov in homeostaza kalcija v astrocitih

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project number:J3-6790
Name:Dinamične meritve metabolitov in sekundarnih prenašalcev v posameznem astrocitu v celični kulturi

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project number:J3-7605
Name:Nanofiziologija eksocitoze v zdravih in bolezenskih razmerah

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