Oleanolic acid alters multiple cell signaling pathways : implication in cancer prevention and therapy

Žiberna, Lovro (author), Šamec, Dunja (author), Mocan, Andrei (author), Nabavi, Seyed F. (author), Bishayee, Anupam (author), Farooqi, Ammad Ahmad (author), Sureda, Antoni (author), Nabavi, Seyed M. (author)

Nowadays, much attention has been paid to diet and dietary supplements as a cost-effective therapeutic strategy for prevention and treatment of a myriad of chronic and degenerative diseases. Rapidly accumulating scientific evidence achieved through high-throughput technologies has greatly expanded the understanding about the multifaceted nature of cancer. Increasingly, it is being realized that deregulation of spatio-temporally controlled intracellular signaling cascades plays a contributory role in the onset and progression of cancer. Therefore, targeting regulators of oncogenic signaling cascades is essential to prevent and treat cancer. A plethora of preclinical and epidemiological evidences showed promising role of phytochemicals against several types of cancer. Oleanolic acid, a common pentacyclic triterpenoid, is mainly found in olive oil, as well as several plant species. It is a potent inhibitor of cellular inflammatory process and a well-known inducer of phase 2 xenobiotic biotransformation enzymes. Main molecular mechanisms underlying anticancer effects of oleanolic acid are mediated by caspases, 5′ adenosine monophosphate-activated protein kinase, extracellular signal-regulated kinase 1/2, matrix metalloproteinases, pro-apoptotic Bax and bid, phosphatidylinositide 3-kinase/Akt1/mechanistic target of rapamycin, reactive oxygen species/apoptosis signal-regulating kinase 1/p38 mitogen-activated protein kinase, nuclear factor-κB, cluster of differentiation 1, CKD4, s6k, signal transducer and activator of transcription 3, as well as aforementioned signaling pathways. In this work, we critically review the scientific literature on the molecular targets of oleanolic acid implicated in the prevention and treatment of several types of cancer. We also discuss chemical aspects, natural sources, bioavailability, and safety of this bioactive phytochemical.

• Language: English
• Keywords: healthy diet, oleanolic acid, anticancer effect, olive, signaling pathways
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2017
• Number of pages: 16 str.
• Numbering: Vol. 18, iss. 3, art. 643
• PID: 20.500.12556/RUL-131184
• UDC: 613.2
• ISSN on article: 1422-0067
• DOI: 10.3390/ijms18030643
• COBISS.SI-ID: 33140953
• Publication date in RUL: 23.09.2021

Record is a part of a journal

• Title: International journal of molecular sciences
• Shortened title: Int. j. mol. sci.
• Publisher: MDPI
• ISSN: 1422-0067
• COBISS.SI-ID: 2779162

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 16.03.2017

Secondary language

• Language: Slovenian
• Keywords: zdrava prehrana, oleinska kislina, učinek proti raku

Projects

• Funder: Other - Other funder or multiple funders
• Funding programme: Spanish Ministry of Health, Social Services and Equality
• Project number: CIBEROBN—CB12/03/30038