Effects of flavonoids from food and dietary supplements on glial and glioblastoma multiforme cells

Vidak, Marko (author), Rozman, Damjana (author), Komel, Radovan (author)

Quercetin, catechins and proanthocyanidins are flavonoids that are prominently featured in foodstuffs and dietary supplements, and may possess anti-carcinogenic activity. Glioblastoma multiforme is the most dangerous form of glioma, a malignancy of the brain connective tissue. This review assesses molecular structures of these flavonoids, their importance as components of diet and dietary supplements, their bioavailability and ability to cross the blood-brain barrier, their reported beneficial health effects, and their effects on non-malignant glial as well as glioblastoma tumor cells. The reviewed flavonoids appear to protect glial cells via reduction of oxidative stress, while some also attenuate glutamate-induced excitotoxicity and reduce neuroinflammation. Most of the reviewed flavonoids inhibit proliferation of glioblastoma cells and induce their death. Moreover, some of them inhibit pro-oncogene signaling pathways and intensify the effect of conventional anti-cancer therapies. However, most of these anti-glioblastoma effects have only been observed in vitro or in animal models. Due to limited ability of the reviewed flavonoids to access the brain, their normal dietary intake is likely insufficient to produce significant anti-cancer effects in this organ, and supplementation is needed.

• Language: English
• Keywords: food, dietary supplements, flavonoids, quercetin, catechins, proanthocyanidins, bioavailability, blood-brain barrier, glial cells, glioblastoma multiforme
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2015
• Number of pages: Str. 19406-19432
• Numbering: Vol. 20, iss. 10
• PID: 20.500.12556/RUL-130391
• UDC: 577
• ISSN on article: 1420-3049
• DOI: 10.3390/molecules201019406
• COBISS.SI-ID: 32258265
• Publication date in RUL: 14.09.2021

Record is a part of a journal

• Title: Molecules
• Shortened title: Molecules
• Publisher: MDPI
• ISSN: 1420-3049
• COBISS.SI-ID: 18462981

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 23.10.2015

Secondary language

• Language: Slovenian
• Keywords: hrana, prehranska dopolnila, flavonoidi

Projects

• Funder: ARRS - Slovenian Research Agency
• Funding programme: Young researchers